Identification of novel mobile colistin resistance gene mcr-10

• Published in: Emerging microbes & infections Vol. 9; no. 1; pp. 508 - 516
• Main Authors: Wang, Chengcheng, Feng, Yu, Liu, Lina, Wei, Li, Kang, Mei, Zong, Zhiyong
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Amino Acid Sequence; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Colistin - pharmacology; Colistin resistance; Databases, Genetic; Drug Resistance, Bacterial; Enterobacter roggenkampii; Enterobacteriaceae - chemistry; Enterobacteriaceae - drug effects; Enterobacteriaceae - genetics; mcr; mcr-10; Models, Molecular; plasmid; Plasmids; Protein Structure, Tertiary; Sequence Analysis, Protein; Enterobacter roggenkampii; plasmid; Colistin resistance; mcr; mcr-10

Mobile colistin resistance (mcr) genes represent an emerging challenge. Here we describe a novel mcr gene, mcr-10, on an IncFIA plasmid of an Enterobacter roggenkampii clinical strain. mcr-10 has the highest nucleotide identity (79.69%) with mcr-9 and encodes MCR-10 with 82.93% amino acids identical...