Phasing out DEHP from plastic indwelling medical devices used for intensive care: Does it reduce the long-term attention deficit of critically ill children?

• Published in: Environment international Vol. 158; p. 106962
• Main Authors: Vanhorebeek, Ilse, Malarvannan, Govindan, Güiza, Fabian, Poma, Giulia, Derese, Inge, Wouters, Pieter J., Joosten, Koen, Verbruggen, Sascha, Jorens, Philippe G., Covaci, Adrian, Van den Berghe, Greet
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2022; Elsevier Science; Elsevier
• Subjects: Attention; Child; Children; Critical Care; Critical Illness; DEHP; Diethylhexyl Phthalate; environment; face; glycemic control; Humans; Medical devices; metabolites; neurodevelopment; phthalates; Plasticizers; Plastics; regression analysis; toxicity; Critical illness; Medical devices; Plasticizers; MEHP; DEHA; Attention; DiNP; ATBC; DINCH; PICU; 5cx-MEPP; DiDP; TGC; TOTM; DPHP; DEHP; UPLC-MS/MS; 5OH-MEHP; ICU; Children; PEPaNIC trial; 5oxo-MEHP; DEHTP; PN

[Display omitted] •Exposure of critically ill children to DEHP in the PICU decreased over the years.•Reduced DEHP exposure in the PICU did not result in improved long-term attention.•Whether alternative plasticizers are neurodevelopmentally safe remains unclear. Children who have been critically ill...