Golgi inCOGnito: From vesicle tethering to human disease

• Published in: Biochimica et biophysica acta. General subjects Vol. 1864; no. 11; p. 129694
• Main Authors: D'Souza, Zinia, Taher, Farhana S., Lupashin, Vladimir V.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2020
• Subjects: Adaptor Proteins, Vesicular Transport - genetics; Adaptor Proteins, Vesicular Transport - metabolism; Animals; Biological Transport; CDG; COG complex; COG-CDG; Congenital Disorders of Glycosylation - genetics; Congenital Disorders of Glycosylation - metabolism; Congenital Disorders of Glycosylation - pathology; endosomes; Glycosylation; Golgi; Golgi Apparatus - genetics; Golgi Apparatus - metabolism; Golgi Apparatus - pathology; homeostasis; human diseases; Humans; Multiprotein Complexes - genetics; Multiprotein Complexes - metabolism; Mutation; patients; physiological transport; Protein Interaction Maps; protein secretion; Protein Subunits - genetics; Protein Subunits - metabolism; proteins; Vesicle tethering; PNA; HLH; TRAPP; CDG; EELS; CHO; GEARs; SNARE; Vesicle tethering; CATCHR; KD; Golgi; COG-CDG; COG; NIHF; WT; GSL; KO; CCD; MS; COG complex; EM; Glycosylation; HOPS; IEF; SNAP; ER; Y2H; AP; HEK; PI4P; RCA; ARF; CCT; HPA; GARP; TM; EARP; TGN; BFA; MTC; PM; COPI/COPII; LVH

The Conserved Oligomeric Golgi (COG) complex, a multi-subunit vesicle tethering complex of the CATCHR (Complexes Associated with Tethering Containing Helical Rods) family, controls several aspects of cellular homeostasis by orchestrating retrograde vesicle traffic within the Golgi. The COG complex i...