Risk factors analysis for hyperuricemic nephropathy among CKD stages 3-4 patients: an epidemiological study of hyperuricemia in CKD stages 3-4 patients in Ningbo, China

• Published in: Renal failure Vol. 40; no. 1; pp. 665 - 670
• Main Authors: Wu, Yong-Yao, Qiu, Xiao-Hui, Ye, Yun, Gao, Chao, Wu, Fuquan, Xia, Guihua
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.11.2018; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Adult; Aged; Biochemical characteristics; Blood Pressure; Body Mass Index; China - epidemiology; CKD 3-4; Clinical Study; Correlation analysis; Epidemiologic Studies; Epidemiology; Female; Gene expression; High density lipoprotein; hUAT; Humans; Hyperuricemia; Hyperuricemia - blood; Hyperuricemia - epidemiology; hyperuricemic nephropathy; Male; Middle Aged; Morbidity; mRNA; Nephropathy; Organic Anion Transporters - genetics; Organic Cation Transport Proteins - genetics; Regression Analysis; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - epidemiology; Risk Factors; RNA, Messenger - analysis; serum uric acid; Sex Factors; Uric acid; Uric Acid - blood; hUAT; hyperuricemia; serum uric acid; hyperuricemic nephropathy; CKD 3–4
• ISSN: 0886-022X; 1525-6049
• DOI: 10.1080/0886022X.2018.1487859

Objective: Uric acid (UA) is a risk marker of CKD and SUA level in CKD 3-4 patients closely correlates with hyperuricemic nephropathy (HN) morbidity. This study was designed to evaluate the risk factors for HN in CKD 3-4 patients. Methods: The 461 CKD 3-4 patients were recruited and all patients were divided into three groups (24 h UUA normal, underexeret, and overproduct type groups) according to the 24 h UUA level after receiving low purine food for five days. Clinical and biochemical characteristics of CKD patients were collected for the logistic regression analysis. Correlation analysis of the mRNA relative expression level of hUAT and hURAT1 with serum UA (SUA) level also was evaluated. Results: There were significant increases in characteristics including average age, waist-to-height ratio (WHR), SUA levels, HN ratio, TG/HDL ratio, body mass index (BMI), blood pressure (BP), uNgal/Cr. ratio, and uKim-1/Cr. ratio in overproduct type group in comparison with the other two groups. Logistic regression analysis showed SUA, CHO, uKim-1/Cr. ratio and uNgal/Cr. ratio were independent and multiple risk factors for HN. Moreover, hUAT and hURAT1 mRNA relative expression levels were significantly correlated with SUA level in the underexeret type CKD 3-4 patients. Conclusions: These results showed SUA and other characteristics contributed to HN morbidity in CKD 3-4 patients.