Total synthesis and anti-viral activities of an extract of Radix isatidis
Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract,...
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Published in | Molecules (Basel, Switzerland) Vol. 19; no. 12; pp. 20906 - 20912 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Abstract | Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract, the isoquinoline derivative 1 was isolated for the first time and has shown better anti-viral activity than other constituents. In this study, to solve the problem of sourcing sufficient quantities of compound 1, a total synthesis route is described, and several analogues are also evaluated for their anti-viral activities. Among them, compound 8 shown potent anti-viral activity with an IC50 value of 15.3 µg/mL. The results suggested that isoquinoline derivatives possessed potent anti-viral activity and are worthy further development. |
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AbstractList | Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract, the isoquinoline derivative 1 was isolated for the first time and has shown better anti-viral activity than other constituents. In this study, to solve the problem of sourcing sufficient quantities of compound 1, a total synthesis route is described, and several analogues are also evaluated for their anti-viral activities. Among them, compound 8 shown potent anti-viral activity with an IC50 value of 15.3 mu g/mL. The results suggested that isoquinoline derivatives possessed potent anti-viral activity and are worthy further development. Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract, the isoquinoline derivative 1 was isolated for the first time and has shown better anti-viral activity than other constituents. In this study, to solve the problem of sourcing sufficient quantities of compound 1, a total synthesis route is described, and several analogues are also evaluated for their anti-viral activities. Among them, compound 8 shown potent anti-viral activity with an IC50 value of 15.3 µg/mL. The results suggested that isoquinoline derivatives possessed potent anti-viral activity and are worthy further development. Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract, the isoquinoline derivative 1 was isolated for the first time and has shown better anti-viral activity than other constituents. In this study, to solve the problem of sourcing sufficient quantities of compound 1 , a total synthesis route is described, and several analogues are also evaluated for their anti-viral activities. Among them, compound 8 shown potent anti-viral activity with an IC 50 value of 15.3 µg/mL. The results suggested that isoquinoline derivatives possessed potent anti-viral activity and are worthy further development. |
Author | Li, Wei Chen, Yu-Qing Wang, Tian-Lin Yang, Jing-Yan He, Li-Wei Liu, Hua-Qing |
AuthorAffiliation | 2 The Second Hospital of Nanjing, 1-1 ZhongFu Road, Nanjing 210003, China; E-Mail: layuer@163.com 1 School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China; E-Mails: he_lw@163.com (L.-W.H.); drcoreychen@gmail.com (Y.-Q.C.); jingyan_1024@163.com (J.-Y.Y.) |
AuthorAffiliation_xml | – name: 1 School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China; E-Mails: he_lw@163.com (L.-W.H.); drcoreychen@gmail.com (Y.-Q.C.); jingyan_1024@163.com (J.-Y.Y.) – name: 2 The Second Hospital of Nanjing, 1-1 ZhongFu Road, Nanjing 210003, China; E-Mail: layuer@163.com |
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References | He (ref4) 2005; 22 ref2 He (ref3) 2013; 44 ref1 Wang (ref6) 2012; 22 He (ref5) 2006; 41 |
References_xml | – volume: 22 start-page: 37 year: 2005 ident: ref4 article-title: Research progress of Radix isatidis against virus publication-title: Inform. Tradit. Chin. Med. contributor: fullname: He – ident: ref2 doi: 10.1142/S0192415X10007749 – volume: 41 start-page: 1193 year: 2006 ident: ref5 article-title: Chemical constituents from water extract of Radix isatidis publication-title: Yao Xue Xue Bao contributor: fullname: He – volume: 44 start-page: 2960 year: 2013 ident: ref3 article-title: Chemical constituents in antiviral fraction of Isatidis Radix and their activities publication-title: Zhong Cao Yao contributor: fullname: He – ident: ref1 doi: 10.1142/S0192415X1350050X – volume: 22 start-page: 268 year: 2012 ident: ref6 article-title: Synthesis and anti-cancer activities of novel 6-arylindenoisoquinolines publication-title: Chin. J. Med. Chem. contributor: fullname: Wang |
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Snippet | Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our... Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our... |
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SubjectTerms | Animals anti-viral activity Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Cell Survival - drug effects Cercopithecus aethiops China Chinese medicine Constituents Derivatives Drugs, Chinese Herbal - chemistry Herpesvirus 1, Human - drug effects Inhibitory Concentration 50 isoquinoline derivative Isoquinolines - chemical synthesis Isoquinolines - pharmacology Radix isatidis Sourcing Sulfuric acid Synthesis Traditional chinese medicine Vero Cells |
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Title | Total synthesis and anti-viral activities of an extract of Radix isatidis |
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