Synthesis and biological assessment of indole derivatives containing penta-heterocycles scaffold as novel anticancer agents towards A549 and K562 cells - Zhang, Guanglong; Tang, Zhenhua; Fan, Sili; Li, Chengpeng; Li, Yan; Liu, Weiqin; Long, Xuesha; Zhang, Wenjing; Zhang, Yi; Li, Zhurui; Wang, Zhenchao; Chen, Danping; et al. (Journal of enzyme inhibition and medicinal chemistry, 2023)
Keywords: anticancer; Antineoplastic Agents; Antitumor agents; Apoptosis; Biochemistry & Molecular Biology; Bioengineering; Cancer therapies; Cell cycle; Cell Line, Tumor; Cell Proliferation; Chemistry, Medicinal; Chemotherapy; Cytotoxicity; Design; Drug Screening Assays, Antitumor; Drugs; Enzymes; Humans; Indole derivatives; Indoles; Indoles - pharmacology; K562 Cells; Leukemia; Life Sciences & Biomedicine; Lung cancer; MDM2 protein; molecular docking; Molecular Docking Simulation; Molecular Structure; penta-heterocycle; Pharmaceutical sciences; Pharmacology & Pharmacy; Prostate cancer; R&D; Research & development; Research Paper; Rubiaceae - metabolism; Science & Technology; Structure-Activity Relationship; MIGRATION; DESIGN; ACTIVATION; P53 FUNCTION; 1,3,4-OXADIAZOLE; anticancer; DISCOVERY; penta-heterocycle; EGFR INHIBITORS; PYRAZOLE; molecular docking; PATHWAY; Indole derivatives; QUINAZOLINONE DERIVATIVES