Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension
The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes...
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| Published in | Emerging microbes & infections Vol. 9; no. 1; pp. 757 - 760 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Taylor & Francis
01.01.2020
Taylor & Francis Ltd Taylor & Francis Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. COVID-19 patients with hypertension were enrolled to evaluate the effect of RAS inhibitors. We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a lower level of IL-6 in peripheral blood. In addition, ACEI or ARB therapy increased CD3 and CD8 T cell counts in peripheral blood and decreased the peak viral load compared to other antihypertensive drugs. This evidence supports the benefit of using ACEIs or ARBs to potentially contribute to the improvement of clinical outcomes of COVID-19 patients with hypertension. |
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| AbstractList | The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. COVID-19 patients with hypertension were enrolled to evaluate the effect of RAS inhibitors. We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a lower level of IL-6 in peripheral blood. In addition, ACEI or ARB therapy increased CD3 and CD8 T cell counts in peripheral blood and decreased the peak viral load compared to other antihypertensive drugs. This evidence supports the benefit of using ACEIs or ARBs to potentially contribute to the improvement of clinical outcomes of COVID-19 patients with hypertension. The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. COVID-19 patients with hypertension were enrolled to evaluate the effect of RAS inhibitors. We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a lower level of IL-6 in peripheral blood. In addition, ACEI or ARB therapy increased CD3 and CD8 T cell counts in peripheral blood and decreased the peak viral load compared to other antihypertensive drugs. This evidence supports the benefit of using ACEIs or ARBs to potentially contribute to the improvement of clinical outcomes of COVID-19 patients with hypertension.The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. COVID-19 patients with hypertension were enrolled to evaluate the effect of RAS inhibitors. We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a lower level of IL-6 in peripheral blood. In addition, ACEI or ARB therapy increased CD3 and CD8 T cell counts in peripheral blood and decreased the peak viral load compared to other antihypertensive drugs. This evidence supports the benefit of using ACEIs or ARBs to potentially contribute to the improvement of clinical outcomes of COVID-19 patients with hypertension. |
| Author | Bi, Jing Wang, Zhaoqin Meng, Juan Xiao, Guohui Yang, Rongqing Di, Wencheng Liu, Lei Zhang, Juanjuan He, Xing Gao, Hong Li, Zigang Ou, Min Zhang, Guoliang |
| Author_xml | – sequence: 1 givenname: Juan surname: Meng fullname: Meng, Juan organization: Shenzhen Bay Laboratory – sequence: 2 givenname: Guohui surname: Xiao fullname: Xiao, Guohui organization: Shenzhen Bay Laboratory – sequence: 3 givenname: Juanjuan surname: Zhang fullname: Zhang, Juanjuan organization: National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology – sequence: 4 givenname: Xing surname: He fullname: He, Xing organization: National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology – sequence: 5 givenname: Min surname: Ou fullname: Ou, Min organization: National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology – sequence: 6 givenname: Jing surname: Bi fullname: Bi, Jing organization: National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology – sequence: 7 givenname: Rongqing surname: Yang fullname: Yang, Rongqing organization: National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology – sequence: 8 givenname: Wencheng surname: Di fullname: Di, Wencheng organization: National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology – sequence: 9 givenname: Zhaoqin surname: Wang fullname: Wang, Zhaoqin organization: National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology – sequence: 10 givenname: Zigang surname: Li fullname: Li, Zigang organization: Shenzhen Bay Laboratory – sequence: 11 givenname: Hong surname: Gao fullname: Gao, Hong email: gaoh0508@163.com organization: National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology – sequence: 12 givenname: Lei surname: Liu fullname: Liu, Lei email: liulei3322@aliyun.com organization: National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology – sequence: 13 givenname: Guoliang orcidid: 0000-0002-3617-5449 surname: Zhang fullname: Zhang, Guoliang email: szdsyy@aliyun.com organization: Lead Contact |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32228222$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1001/jama.2020.2648 10.1016/j.yexmp.2019.104350 10.1258/ebm.2012.012123 10.33549/physiolres.932861 10.1161/HYPERTENSIONAHA.119.13197 10.1038/s41586-020-2951-z 10.1038/nm1267 10.1007/s11427-020-1643-8 10.1038/srep07027 10.1159/000076766 |
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| SubjectTerms | Aged Angiotensin II Type 1 Receptor Blockers - therapeutic use angiotensin II type1 receptor blockers angiotensin-converting enzyme inhibitors Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive Agents - therapeutic use Betacoronavirus C-Reactive Protein - analysis CD3 Complex CD8-Positive T-Lymphocytes - cytology China Clinical outcomes Coronavirus Infections - complications Coronavirus Infections - drug therapy Coronaviruses COVID-19 Diuretics Female Humans Hypertension Hypertension - complications Hypertension - drug therapy Hypertension - virology Interleukin-6 - blood Letter Male Middle Aged Pandemics Pneumonia, Viral - complications Pneumonia, Viral - drug therapy Renin-Angiotensin System Retrospective Studies SARS-CoV-2 Treatment Outcome Viral Load |
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| Title | Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension |
| URI | https://www.tandfonline.com/doi/abs/10.1080/22221751.2020.1746200 https://www.ncbi.nlm.nih.gov/pubmed/32228222 https://www.proquest.com/docview/2508725839 https://www.proquest.com/docview/2385270678 https://pubmed.ncbi.nlm.nih.gov/PMC7170368 https://doaj.org/article/ec70bd2cddfc4c57b75530b8badb6707 |
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