Gemcitabine-Induced Hemolytic Uremic Syndrome in Pancreatic Cancer: A Case Report and Review of the Literature
Hemolytic uremic syndrome (HUS) is a rare thrombotic complication characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS may be caused by several different conditions, including infection, malignancy, and chemotherapeutic agents, such as mitomyc...
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| Published in | Gut and liver Vol. 8; no. 1; pp. 109 - 112 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Korea (South)
The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Pancreatobiliary Association; Korean Society of Gastrointestinal Cancer
01.01.2014
Gastroenterology Council for Gut and Liver 거트앤리버 소화기연관학회협의회 |
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| Online Access | Get full text |
| ISSN | 1976-2283 2005-1212 2005-1212 |
| DOI | 10.5009/gnl.2014.8.1.109 |
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| Abstract | Hemolytic uremic syndrome (HUS) is a rare thrombotic complication characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS may be caused by several different conditions, including infection, malignancy, and chemotherapeutic agents, such as mitomycin, cisplatin, and most recently, gemcitabine. The outcome of gemcitabine-induced HUS is poor, and the disease has a high mortality rate. This study reports a case of gemcitabine-induced HUS in a patient with pancreatic cancer in Korea. |
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| AbstractList | Background/AimsThe prognosis of pancreatic adenocarcinoma (PAC) is poor. The serum carbohydrate antigen 19-9 (CA 19-9) level has been identified as a prognostic indicator of recurrence and reduced overall survival. The aim of this study was to identify preoperative prognostic factors and to create a prognostic model able to assess the early recurrence risk for patients with resectable PAC.Methods : A series of 177 patients with PAC treated surgically at the St. Andrea Hospital of Rome between January 2003 and December 2011 were reviewed retrospectively. Univariate and multivariate analyses were utilized to identify preoperative prognostic indicators.Results : A preoperative CA 19-9 level >228 U/mL, tumor size >3.1 cm, and the presence of pathological preoperative lymph nodes statistically correlated with early recurrence. Together, these three factors predicted the possibility of an early recurrence with 90.4% accuracy. The combination of these three preoperative conditions was identified as an independent parameter for early recurrence based on multivariate analysis (p=0.0314; hazard ratio, 3.9811; 95% confidence interval, 1.1745 to 15.3245).Conclusion : sPAC patient candidates for surgical resection should undergo an assessment of early recurrence risk to avoid unnecessary and ineffective resection and to identify patients for whom palliative or alternative treatment may be the treatment of choice. Hemolytic uremic syndrome (HUS) is a rare thrombotic complication characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS may be caused by several different conditions, including infection, malignancy, and chemotherapeutic agents, such as mitomycin, cisplatin, and most recently, gemcitabine. The outcome of gemcitabine-induced HUS is poor, and the disease has a high mortality rate. This study reports a case of gemcitabine-induced HUS in a patient with pancreatic cancer in Korea.Hemolytic uremic syndrome (HUS) is a rare thrombotic complication characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS may be caused by several different conditions, including infection, malignancy, and chemotherapeutic agents, such as mitomycin, cisplatin, and most recently, gemcitabine. The outcome of gemcitabine-induced HUS is poor, and the disease has a high mortality rate. This study reports a case of gemcitabine-induced HUS in a patient with pancreatic cancer in Korea. Hemolytic uremic syndrome (HUS) is a rare thrombotic complication characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS may be caused by several different conditions, including infection, malignancy, and chemotherapeutic agents, such as mitomycin, cisplatin, and most recently, gemcitabine. The outcome of gemcitabine-induced HUS is poor, and the disease has a high mortality rate. This study reports a case of gemcitabine-induced HUS in a patient with pancreatic cancer in Korea. Hemolytic uremic syndrome (HUS) is a rare thrombotic complication characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS may be caused by several different conditions, including infection, malignancy, and chemotherapeutic agents, such as mitomycin, cisplatin, and most recently, gemcitabine. The outcome of gemcitabine-induced HUS is poor, and the disease has a high mortality rate. This study reports a case of gemcitabine-induced HUS in a patient with pancreatic cancer in Korea. KCI Citation Count: 14 |
| Author | Choi, Youn Jeong Kang, Huapyong Kim, Jin Seok Song, Si Young Chung, Moon Jae Choi, Heun Lee, Kyung Joo Lee, Hye Won Lee, Seung Woo Han†, Seung Hyuk |
| AuthorAffiliation | Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea |
| AuthorAffiliation_xml | – name: Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea – name: Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea – name: Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea |
| Author_xml | – sequence: 1 givenname: Hye Won surname: Lee fullname: Lee, Hye Won – sequence: 2 givenname: Moon Jae surname: Chung fullname: Chung, Moon Jae – sequence: 3 givenname: Huapyong surname: Kang fullname: Kang, Huapyong – sequence: 4 givenname: Heun surname: Choi fullname: Choi, Heun – sequence: 5 givenname: Youn Jeong surname: Choi fullname: Choi, Youn Jeong – sequence: 6 givenname: Kyung Joo surname: Lee fullname: Lee, Kyung Joo – sequence: 7 givenname: Seung Woo surname: Lee fullname: Lee, Seung Woo – sequence: 8 givenname: Seung Hyuk surname: Han† fullname: Han†, Seung Hyuk – sequence: 9 givenname: Jin Seok surname: Kim fullname: Kim, Jin Seok – sequence: 10 givenname: Si Young surname: Song fullname: Song, Si Young |
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| Cites_doi | 10.1053/ajkd.2002.35758 10.4046/trd.2012.72.2.207 10.1097/MCG.0b013e31802da22e 10.1002/jca.20213 10.1038/sj.bjc.6690242 10.1016/j.ygyno.2004.12.027 10.1097/COC.0b013e3182005783 10.1002/cncr.20290 10.1007/s00280-008-0900-x 10.1016/S0272-6386(99)70194-0 10.5414/CNP71130 10.1159/000013525 10.1097/00001813-199907000-00004 10.1007/BF00873232 10.1002/(SICI)1097-0142(19990501)85:9<2023::AID-CNCR21>3.0.CO;2-2 10.1007/s00277-007-0429-9 10.12659/AJCR.882858 |
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| Keywords | Gemcitabine Hemolytic-uremic syndrome Pancreatic neoplasms |
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| Snippet | Hemolytic uremic syndrome (HUS) is a rare thrombotic complication characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute... Background/AimsThe prognosis of pancreatic adenocarcinoma (PAC) is poor. The serum carbohydrate antigen 19-9 (CA 19-9) level has been identified as a... |
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| SubjectTerms | Antimetabolites, Antineoplastic - adverse effects Case Report Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives gemcitabine hemolytic-uremic syndrome Hemolytic-Uremic Syndrome - chemically induced Humans Male Middle Aged pancreatic neoplasms Pancreatic Neoplasms - drug therapy Treatment Outcome 내과학 |
| Title | Gemcitabine-Induced Hemolytic Uremic Syndrome in Pancreatic Cancer: A Case Report and Review of the Literature |
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