Active vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK–mTOR signaling pathway

• Published in: Biochemistry and cell biology Vol. 98; no. 3; pp. 434 - 442
• Main Authors: Kong, Chunyu, Wang, Changlei, Shi, Yuquan, Yan, Lei, Xu, Junhua, Qi, Wufang
• Format: Journal Article
• Language: English
• Published: 1840 Woodward Drive, Suite 1, Ottawa, ON K2C 0P7 NRC Research Press 01.05.2020; Canadian Science Publishing NRC Research Press
• Subjects: 25-Hydroxyvitamin D; active vitamin D; Alfacalcidol; AMP-Activated Protein Kinases - metabolism; AMPK–mTOR signaling pathway; Analysis; Animals; Antibodies; Arthritis; autophagie; Autophagy; Biomedical materials; Bone and Bones - metabolism; Calcifediol; Calciferol; Cartilage; Cartilage diseases; Cell Survival; Cells, Cultured; Chondrocytes; Chondrocytes - cytology; Chondrocytes - metabolism; Coloration; composé C; compound C; Diagnostic systems; Disease Models, Animal; Female; Green Fluorescent Proteins - metabolism; Health aspects; Humans; Inflammation; Inhibitors; Interleukin 6; Interleukins; Male; Mice; Middle Aged; Osteoarthritis; Osteoarthritis - drug therapy; ostéo-arthrite; Phagocytosis; Phagosomes; Safranine; Serum levels; Sexually transmitted diseases; Signal Transduction; Signaling; Signs and symptoms; STD; TOR protein; TOR Serine-Threonine Kinases - metabolism; Transfection; Tumor necrosis factor-α; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D - pharmacology; vitamine D active; voie de signalisation AMPK–mTOR; Western blotting; Massachusetts; China; vitamine D active; ostéo-arthrite; autophagy; autophagie; compound C; osteoarthritis; voie de signalisation AMPK–mTOR; composé C; active vitamin D; AMPK–mTOR signaling pathway

Osteoarthritis (OA) is a common joint degenerative disease. Vitamin D (VD) is essential for bone health. We hypothesized that active VD could be used as a therapeutic treatment for OA. Low serum levels of 25-hydroxyvitamin D [25(OH)D] have been found in patients with OA, and thus the serum level of...