Active vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK–mTOR signaling pathway - Kong, Chunyu; Wang, Changlei; Shi, Yuquan; Yan, Lei; Xu, Junhua; Qi, Wufang (Biochemistry and cell biology, 2020)
Keywords: 25-Hydroxyvitamin D; active vitamin D; Alfacalcidol; AMP-Activated Protein Kinases - metabolism; AMPK–mTOR signaling pathway; Analysis; Animals; Antibodies; Arthritis; autophagie; Autophagy; Biomedical materials; Bone and Bones - metabolism; Calcifediol; Calciferol; Cartilage; Cartilage diseases; Cell Survival; Cells, Cultured; Chondrocytes; Chondrocytes - cytology; Chondrocytes - metabolism; Coloration; composé C; compound C; Diagnostic systems; Disease Models, Animal; Female; Green Fluorescent Proteins - metabolism; Health aspects; Humans; Inflammation; Inhibitors; Interleukin 6; Interleukins; Male; Mice; Middle Aged; Osteoarthritis; Osteoarthritis - drug therapy; ostéo-arthrite; Phagocytosis; Phagosomes; Safranine; Serum levels; Sexually transmitted diseases; Signal Transduction; Signaling; Signs and symptoms; STD; TOR protein; TOR Serine-Threonine Kinases - metabolism; Transfection; Tumor necrosis factor-α; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D - pharmacology; vitamine D active; voie de signalisation AMPK–mTOR; Western blotting; Massachusetts; China; vitamine D active; ostéo-arthrite; autophagy; autophagie; compound C; osteoarthritis; voie de signalisation AMPK–mTOR; composé C; active vitamin D; AMPK–mTOR signaling pathway