Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis

• Published in: Drug delivery Vol. 29; no. 1; pp. 214 - 228
• Main Authors: Yan, Chengqi, Chen, Jing, Wang, Cheng, Yuan, Meng, Kang, Yu, Wu, Zihan, Li, Wenqing, Zhang, Guolei, Machens, Hans-Günther, Rinkevich, Yuval, Chen, Zhenbing, Yang, Xiaofan, Xu, Xiang
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Angiogenesis; Animals; Diabetes; Diabetes Mellitus, Experimental - complications; diabetic wound; Drug Carriers - metabolism; drug delivery; Exosomes - metabolism; Gene expression; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred BALB C; MicroRNAs; MicroRNAs - administration & dosage; MicroRNAs - pharmacology; Milk; Milk-derived exosomes; miR-31-5p; Neovascularization, Physiologic - drug effects; Wound healing; Wound Healing - drug effects; Wounds and Injuries - etiology; Wounds and Injuries - pathology; diabetic wound; drug delivery; angiogenesis; Milk-derived exosomes; miR-31-5p

The refractory diabetic wound has remained a worldwide challenge as one of the major health problems. The impaired angiogenesis phase during diabetic wound healing partly contributes to the pathological process. MicroRNA (miRNA) is an essential regulator of gene expression in crucial biological proc...