Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens

• Published in: Research in microbiology Vol. 169; no. 7-8; pp. 450 - 454
• Main Authors: Hassan, Karl A., Liu, Qi, Elbourne, Liam D.H., Ahmad, Irshad, Sharples, David, Naidu, Varsha, Chan, Chak Lam, Li, Liping, Harborne, Steven P.D., Pokhrel, Alaska, Postis, Vincent L.G., Goldman, Adrian, Henderson, Peter J.F., Paulsen, Ian T.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.09.2018; Elsevier
• Subjects: amino acid motifs; amino acid sequences; animal pathogens; anti-infective agents; Antimicrobial resistance; antiseptics; Bacterial transmembrane pair domain; biocides; disinfectants; drug resistance; Efflux; genes; germplasm conservation; Gram-negative bacteria; Gram-negative pathogen; interspersed repetitive sequences; Membrane transport; PACE; transporters; Efflux; Antimicrobial resistance; Bacterial transmembrane pair domain; Gram-negative pathogen; Membrane transport; PACE

The proteobacterial antimicrobial compound efflux (PACE) family of transport proteins was only recently described. PACE family transport proteins can confer resistance to a range of biocides used as disinfectants and antiseptics, and are encoded by many important Gram-negative human pathogens. Howev...