The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism

• Published in: Biochimica et biophysica acta Vol. 1822; no. 9; pp. 1397 - 1410
• Main Authors: Hunt, Mary C., Siponen, Marina I., Alexson, Stefan E.H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2012
• Subjects: Acyl Coenzyme A - metabolism; Acyl-CoA thioesterase; Acyltransferases - genetics; Acyltransferases - metabolism; Acyltransferases - physiology; Animals; Bile acid-CoA:amino acid N-acyltransferase; Bile Acids and Salts - metabolism; Cholic Acids - blood; Cholic Acids - genetics; Coenzyme A; Humans; Hydrolysis; Lipid Metabolism; Medicin och hälsovetenskap; Models, Molecular; N-Acyl taurine; Palmitoyl-CoA Hydrolase - chemistry; Palmitoyl-CoA Hydrolase - metabolism; Palmitoyl-CoA Hydrolase - physiology; Peroxisome; Peroxisomes - enzymology; Peroxisomes - metabolism; Protein Conformation; Protein structure; Steroid Metabolism, Inborn Errors - enzymology; Steroid Metabolism, Inborn Errors - genetics; CDCA; DMN-CoA; NAT; FXR; FAAH; HNF-4α; PTS1; CoASH; N-Acyl taurine; ACNAT; BAAT; 4-HNE; PPAR; Acyl-CoA thioesterase; Peroxisome; ACOT; Coenzyme A; HAO1; Bile acid-CoA:amino acid N-acyltransferase; ACOX3; Protein structure; CA

The importance of peroxisomes in lipid metabolism is now well established and peroxisomes contain approximately 60 enzymes involved in these lipid metabolic pathways. Several acyl-CoA thioesterase enzymes (ACOTs) have been identified in peroxisomes that catalyze the hydrolysis of acyl-CoAs (short-,...