Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients

Immune system-related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell (2TH) cytokine is involved in the regulation of immune responses. Hence, this study was designed to explore the association between MS and polymorphisms in the -590 reg...

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Published inAnnals of Saudi medicine Vol. 32; no. 2; pp. 127 - 130
Main Authors Arababadi, Mohammad Kazemi, Mosavi, Reza, Ravari, Ali, Teimori, Hossein, Hassanshahi, Gholamhossein
Format Journal Article
LanguageEnglish
Published Saudi Arabia Medknow Publications and Media Pvt. Ltd 01.03.2012
KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE
King Faisal Specialist Hospital and Research Centre
Subjects
Adult
Alleles
Case-Control Studies
Cytokines
Deoxyribonucleic acid
DNA
Equilibrium
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genetic testing
Genotype
Genotype & phenotype
Humans
Immune system
Interleukin-4 - genetics
Iran
Male
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - genetics
Original
Pathogenesis
Patients
Polymorphism
Polymorphism, Restriction Fragment Length
Population
Socioeconomic factors
Statistical analysis
Studies
Iran
United States > US
Online AccessGet full text

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Abstract Immune system-related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell (2TH) cytokine is involved in the regulation of immune responses. Hence, this study was designed to explore the association between MS and polymorphisms in the -590 region of IL-4. A descriptive study at Rafsanjan University of Medical Sciences, Rafsnajan from September 2009 to August 2010. Blood samples were collected from 100 MS patients and 150 healthy controls on EDTA precoated tubes. DNA was extracted and analyzed for IL-4 polymorphisms using restricted fragment length polymorphism in patients and controls. Demographic data were also collected by a questionnaire that was designed specifically for this study. We observed a significant difference in the C/C, T/C, and T/T genotypes of the -590 region of IL-4 between patients with MS and healthy controls (P<.001). We conclude that functional polymorphisms of IL-4 possibly play a crucial role in the pathogenesis of MS.
AbstractList BACKGROUND AND OBJECTIVES: Immune system–related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell (2TH) cytokine is involved in the regulation of immune responses. Hence, this study was designed to explore the association between MS and polymorphisms in the -590 region of IL-4. DESIGN AND SETTING: A descriptive study at Rafsanjan University of Medical Sciences, Rafsnajan from September 2009 to August 2010. PATIENTS AND METHODS: Blood samples were collected from 100 MS patients and 150 healthy controls on EDTA precoated tubes. DNA was extracted and analyzed for IL-4 polymorphisms using restricted fragment length polymorphism in patients and controls. Demographic data were also collected by a questionnaire that was designed specifically for this study. RESULTS: We observed a significant difference in the C/C, T/C, and T/T genotypes of the -590 region of IL-4 between patients with MS and healthy controls (P< .001). CONCLUSIONS: We conclude that functional polymorphisms of IL-4 possibly play a crucial role in the pathogenesis of MS.
BACKGROUND AND OBJECTIVESImmune system-related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell (2TH) cytokine is involved in the regulation of immune responses. Hence, this study was designed to explore the association between MS and polymorphisms in the -590 region of IL-4. DESIGN AND SETTINGA descriptive study at Rafsanjan University of Medical Sciences, Rafsnajan from September 2009 to August 2010. PATIENTS AND METHODSBlood samples were collected from 100 MS patients and 150 healthy controls on EDTA precoated tubes. DNA was extracted and analyzed for IL-4 polymorphisms using restricted fragment length polymorphism in patients and controls. Demographic data were also collected by a questionnaire that was designed specifically for this study. RESULTSWe observed a significant difference in the C/C, T/C, and T/T genotypes of the -590 region of IL-4 between patients with MS and healthy controls (P<.001). CONCLUSIONSWe conclude that functional polymorphisms of IL-4 possibly play a crucial role in the pathogenesis of MS.
Immune system-related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell (2TH) cytokine is involved in the regulation of immune responses. Hence, this study was designed to explore the association between MS and polymorphisms in the -590 region of IL-4. A descriptive study at Rafsanjan University of Medical Sciences, Rafsnajan from September 2009 to August 2010. Blood samples were collected from 100 MS patients and 150 healthy controls on EDTA precoated tubes. DNA was extracted and analyzed for IL-4 polymorphisms using restricted fragment length polymorphism in patients and controls. Demographic data were also collected by a questionnaire that was designed specifically for this study. We observed a significant difference in the C/C, T/C, and T/T genotypes of the -590 region of IL-4 between patients with MS and healthy controls (P<.001). We conclude that functional polymorphisms of IL-4 possibly play a crucial role in the pathogenesis of MS.
Audience Academic
Author Ravari, Ali
Arababadi, Mohammad Kazemi
Hassanshahi, Gholamhossein
Teimori, Hossein
Mosavi, Reza
AuthorAffiliation c Neurosurgery, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
a Department of Microbiology, Hematology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
e Cellular and Molecular Research Center, School of Medicine, Shahrekord University of Medical Sciences, Sharekord, Iran
b Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
d Nursing, Faculty of Nursing, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
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– name: e Cellular and Molecular Research Center, School of Medicine, Shahrekord University of Medical Sciences, Sharekord, Iran
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  givenname: Mohammad Kazemi
  surname: Arababadi
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  organization: Department of Microbiology, Hematology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Iran
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Snippet Immune system-related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell (2TH) cytokine is involved...
BACKGROUND AND OBJECTIVES: Immune system-related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell...
BACKGROUND AND OBJECTIVES: Immune system–related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell...
BACKGROUND AND OBJECTIVESImmune system-related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell...
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StartPage 127
SubjectTerms Adult
Alleles
Case-Control Studies
Cytokines
Deoxyribonucleic acid
DNA
Equilibrium
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genetic testing
Genotype
Genotype & phenotype
Humans
Immune system
Interleukin-4 - genetics
Iran
Male
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - genetics
Original
Pathogenesis
Patients
Polymorphism
Polymorphism, Restriction Fragment Length
Population
Socioeconomic factors
Statistical analysis
Studies
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Title Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients
URI https://www.ncbi.nlm.nih.gov/pubmed/22366824
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https://pubmed.ncbi.nlm.nih.gov/PMC6086643
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Volume 32
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