Trajectory modeling of endothelial-to-mesenchymal transition reveals galectin-3 as a mediator in pulmonary fibrosis

• Published in: Cell death & disease Vol. 12; no. 4; p. 327
• Main Authors: Jia, Wangyue, Wang, Zhaoyan, Gao, Ceshu, Wu, Jian, Wu, Qiong
• Format: Journal Article
• Language: English
• Published: England Springer Nature B.V 26.03.2021; Nature Publishing Group UK; Nature Publishing Group
• Subjects: AKT protein; Antagonists; Bleomycin; Endothelial cells; Fibrosis; Galectin-3; Lung diseases; Mesenchyme; Microvasculature; Pulmonary fibrosis; siRNA; β-Catenin

The endothelial-to-mesenchymal transition (EndMT) is an important source of fibrotic cells in idiopathic pulmonary fibrosis (IPF). However, how endothelial cells (ECs) are activated and how EndMT impact IPF remain largely elusive. Here, we use unsupervised pseudotemporal analysis to recognize the he...