Gestational and lactational exposition to di-n-butyl phthalate increases neurobehavioral perturbations in rats: A three generational comparative study

• Published in: Toxicology reports Vol. 7; pp. 480 - 491
• Main Authors: P, Mahaboob Basha, M.J., Radha
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.01.2020; Elsevier
• Subjects: Acetylcholinesterase; cognition; cognitive disorders; Cognitive impairments; comparative study; Di-n-butyl phthalate; dibutyl phthalate; Endocrine dysfunction; Hippocampus; hyperplasia; lactation; memory; Multi-generational assessment; pregnancy; Regular; shrinkage; toxicity; vacuoles; Cognitive impairments; Multi-generational assessment; Acetylcholinesterase; Hippocampus; Di-n-butyl phthalate; Endocrine dysfunction

[Display omitted] •DBP intoxicated F3 progeny scored low in sensorimotor-indices than F1 and F2.•A higher behavioural discrepancy in F3 progeny and subjects committed more errors.•Correlates between hormonal milieu and behavioural indices signify vulnerability of developing animals.•Deceptive cholin...