Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies - Biancon, Giulia; Joshi, Poorval; Zimmer, Joshua T.; Hunck, Torben; Gao, Yimeng; Lessard, Mark D.; Courchaine, Edward; Barentine, Andrew E.S.; Machyna, Martin; Botti, Valentina; Qin, Ashley; Gbyli, Rana; et al. (Molecular cell, 2022)
Keywords: AML; crosslinking; exons; freCLIP; Humans; introns; Leukemia, Myeloid, Acute - genetics; MDS; mutants; Mutation; Myelodysplastic Syndromes - genetics; nucleotides; precipitin tests; RNA; RNA binding; RNA granules; RNA Splice Sites; RNA Splicing - genetics; RNA-Binding Proteins - genetics; sequence analysis; splicing; Splicing Factor U2AF - genetics; Splicing Factor U2AF - metabolism; stress granules; Stress Granules - metabolism; stress response; U2AF1; AML; stress response; RNA; stress granules; U2AF1; freCLIP; splicing; RNA granules; MDS; RNA binding