An investigation of statistical power for continuous arterial spin labeling imaging at 1.5 T

Variance estimates can be used in conjunction with scientifically meaningful effect sizes to design experiments with type II error control. Here we present estimates of intra- and inter-subject variances for region of interest (ROI) from resting cerebral blood flow (CBF) maps obtained using whole br...

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Published inNeuroImage (Orlando, Fla.) Vol. 39; no. 3; pp. 1246 - 1256
Main Authors Asllani, Iris, Borogovac, Ajna, Wright, Clinton, Sacco, Ralph, Brown, Truman R., Zarahn, Eric
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2008
Elsevier Limited
Subjects
Acquisitions & mergers
Aged
Algorithms
Analysis of Variance
ASL
Brain
CBF
Cerebral Arteries - anatomy & histology
Cerebrovascular Circulation - physiology
Cohort Studies
Echo-Planar Imaging - statistics & numerical data
fMRI
Humans
Image Processing, Computer-Assisted - statistics & numerical data
Intersubject variance
Intrasubject variance
Medical imaging
Reproducibility of Results
Sample variance
Spin Labels
Statistical power
Studies
fMRI
ASL
Intrasubject variance
Statistical power
CBF
Intersubject variance
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Abstract Variance estimates can be used in conjunction with scientifically meaningful effect sizes to design experiments with type II error control. Here we present estimates of intra- and inter-subject variances for region of interest (ROI) from resting cerebral blood flow (CBF) maps obtained using whole brain, spin echo echoplanar (SE-EPI) continuous arterial spin labeling (CASL) imaging on 52 elderly subjects (age=70.5±7.9 years, 29 males). There was substantial intrasubject systematic variability in CBF of gray matter ROIs corresponding to a range of standard deviations=[39–168] (ml/(100 g min)). This variability was mainly due to two factors: (1) an expected inverse relationship between ROI volume and intrasubject variance and (2) an increased effective post-labeling delay for more superior slices acquired later in the sequence. For example, intrasubject variance in Brodmann area 4 (BA 4) was ∼8 times larger than in hippocampus, despite their similar gray matter volumes. Estimated ROI-wise power was computed for various numbers of acquired CBF images, numbers of subjects, and CBF effect sizes for two experimental designs: independent sample t-test and paired t-test. The theoretical effects of pulse sequence and field strength on general applicability of these results are discussed.
AbstractList Variance estimates can be used in conjunction with scientifically meaningful effect sizes to design experiments with type II error control. Here we present estimates of intra- and inter-subject variances for region of interest (ROI) from resting cerebral blood flow (CBF) maps obtained using whole brain, spin echo echoplanar (SE-EPI) continuous arterial spin labeling (CASL) imaging on 52 elderly subjects (age=70.5±7.9 years, 29 males). There was substantial intrasubject systematic variability in CBF of gray matter ROIs corresponding to a range of standard deviations=[39-168] (ml/(100 g min)). This variability was mainly due to two factors: (1) an expected inverse relationship between ROI volume and intrasubject variance and (2) an increased effective post-labeling delay for more superior slices acquired later in the sequence. For example, intrasubject variance in Brodmann area 4 (BA 4) was ~8 times larger than in hippocampus, despite their similar gray matter volumes. Estimated ROI-wise power was computed for various numbers of acquired CBF images, numbers of subjects, and CBF effect sizes for two experimental designs: independent samplet-test and pairedt-test. The theoretical effects of pulse sequence and field strength on general applicability of these results are discussed.
Variance estimates can be used in conjunction with scientifically meaningful effect sizes to design experiments with type II error control. Here we present estimates of intra- and inter-subject variances for region of interest (ROI) from resting cerebral blood flow ( CBF ) maps obtained using whole brain, spin echo echoplanar (SE-EPI) continuous arterial spin labeling (CASL) imaging on 52 elderly subjects (age = 70.5 ± 7.9 years, 29 males). There was substantial intrasubject systematic variability in CBF of gray matter ROIs corresponding to a range of standard deviations = [39 – 168] (mL/(100g·min)). This variability was mainly due to two factors: 1) an expected inverse relationship between ROI volume and intrasubject variance, and 2) an increased effective post-labeling delay for more superior slices acquired later in the sequence. For example, intrasubject variance in Brodmann Area 4 (BA 4) was ∼ 8 times larger than in hippocampus, despite their similar gray matter volumes. Estimated ROI-wise power was computed for various numbers of acquired CBF images, numbers of subjects, and CBF effect sizes for two experimental designs: independent samples t -test and paired t -test. The theoretical effects of pulse sequence and field strength on general applicability of these results are discussed.
Variance estimates can be used in conjunction with scientifically meaningful effect sizes to design experiments with type II error control. Here we present estimates of intra- and inter-subject variances for region of interest (ROI) from resting cerebral blood flow (CBF) maps obtained using whole brain, spin echo echoplanar (SE-EPI) continuous arterial spin labeling (CASL) imaging on 52 elderly subjects (age=70.5+/-7.9 years, 29 males). There was substantial intrasubject systematic variability in CBF of gray matter ROIs corresponding to a range of standard deviations=[39-168] (ml/(100 g min)). This variability was mainly due to two factors: (1) an expected inverse relationship between ROI volume and intrasubject variance and (2) an increased effective post-labeling delay for more superior slices acquired later in the sequence. For example, intrasubject variance in Brodmann area 4 (BA 4) was approximately 8 times larger than in hippocampus, despite their similar gray matter volumes. Estimated ROI-wise power was computed for various numbers of acquired CBF images, numbers of subjects, and CBF effect sizes for two experimental designs: independent sample t-test and paired t-test. The theoretical effects of pulse sequence and field strength on general applicability of these results are discussed.Variance estimates can be used in conjunction with scientifically meaningful effect sizes to design experiments with type II error control. Here we present estimates of intra- and inter-subject variances for region of interest (ROI) from resting cerebral blood flow (CBF) maps obtained using whole brain, spin echo echoplanar (SE-EPI) continuous arterial spin labeling (CASL) imaging on 52 elderly subjects (age=70.5+/-7.9 years, 29 males). There was substantial intrasubject systematic variability in CBF of gray matter ROIs corresponding to a range of standard deviations=[39-168] (ml/(100 g min)). This variability was mainly due to two factors: (1) an expected inverse relationship between ROI volume and intrasubject variance and (2) an increased effective post-labeling delay for more superior slices acquired later in the sequence. For example, intrasubject variance in Brodmann area 4 (BA 4) was approximately 8 times larger than in hippocampus, despite their similar gray matter volumes. Estimated ROI-wise power was computed for various numbers of acquired CBF images, numbers of subjects, and CBF effect sizes for two experimental designs: independent sample t-test and paired t-test. The theoretical effects of pulse sequence and field strength on general applicability of these results are discussed.
Variance estimates can be used in conjunction with scientifically meaningful effect sizes to design experiments with type II error control. Here we present estimates of intra- and inter-subject variances for region of interest (ROI) from resting cerebral blood flow (CBF) maps obtained using whole brain, spin echo echoplanar (SE-EPI) continuous arterial spin labeling (CASL) imaging on 52 elderly subjects (age=70.5+/-7.9 years, 29 males). There was substantial intrasubject systematic variability in CBF of gray matter ROIs corresponding to a range of standard deviations=[39-168] (ml/(100 g min)). This variability was mainly due to two factors: (1) an expected inverse relationship between ROI volume and intrasubject variance and (2) an increased effective post-labeling delay for more superior slices acquired later in the sequence. For example, intrasubject variance in Brodmann area 4 (BA 4) was approximately 8 times larger than in hippocampus, despite their similar gray matter volumes. Estimated ROI-wise power was computed for various numbers of acquired CBF images, numbers of subjects, and CBF effect sizes for two experimental designs: independent sample t-test and paired t-test. The theoretical effects of pulse sequence and field strength on general applicability of these results are discussed.
Variance estimates can be used in conjunction with scientifically meaningful effect sizes to design experiments with type II error control. Here we present estimates of intra- and inter-subject variances for region of interest (ROI) from resting cerebral blood flow (CBF) maps obtained using whole brain, spin echo echoplanar (SE-EPI) continuous arterial spin labeling (CASL) imaging on 52 elderly subjects (age=70.5±7.9 years, 29 males). There was substantial intrasubject systematic variability in CBF of gray matter ROIs corresponding to a range of standard deviations=[39–168] (ml/(100 g min)). This variability was mainly due to two factors: (1) an expected inverse relationship between ROI volume and intrasubject variance and (2) an increased effective post-labeling delay for more superior slices acquired later in the sequence. For example, intrasubject variance in Brodmann area 4 (BA 4) was ∼8 times larger than in hippocampus, despite their similar gray matter volumes. Estimated ROI-wise power was computed for various numbers of acquired CBF images, numbers of subjects, and CBF effect sizes for two experimental designs: independent sample t-test and paired t-test. The theoretical effects of pulse sequence and field strength on general applicability of these results are discussed.
Author Asllani, Iris
Wright, Clinton
Zarahn, Eric
Borogovac, Ajna
Brown, Truman R.
Sacco, Ralph
AuthorAffiliation 1 Department of Biomedical Engineering, Columbia University College of Physicians and Surgeons, 630 West 168 th Street, Columbia University, New York, New York, 10032
2 Department of Epidemiology, Columbia University College of Physicians and Surgeons, 630 West 168 th Street, Columbia University, New York, New York, 10032
4 Department of Psychiatry, Columbia University College of Physicians and Surgeons, 630 West 168 th Street, Columbia University, New York, New York, 10032
5 Department of Radiology, Columbia University College of Physicians and Surgeons, 630 West 168 th Street, Columbia University, New York, New York, 10032
3 Department of Neurology, Columbia University College of Physicians and Surgeons, 630 West 168 th Street, Columbia University, New York, New York, 10032
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SSID ssj0009148
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Snippet Variance estimates can be used in conjunction with scientifically meaningful effect sizes to design experiments with type II error control. Here we present...
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pubmed
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elsevier
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SubjectTerms Acquisitions & mergers
Aged
Algorithms
Analysis of Variance
ASL
Brain
CBF
Cerebral Arteries - anatomy & histology
Cerebrovascular Circulation - physiology
Cohort Studies
Echo-Planar Imaging - statistics & numerical data
fMRI
Humans
Image Processing, Computer-Assisted - statistics & numerical data
Intersubject variance
Intrasubject variance
Medical imaging
Reproducibility of Results
Sample variance
Spin Labels
Statistical power
Studies
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Title An investigation of statistical power for continuous arterial spin labeling imaging at 1.5 T
URI https://www.clinicalkey.com/#!/content/1-s2.0-S1053811907009536
https://dx.doi.org/10.1016/j.neuroimage.2007.10.015
https://www.ncbi.nlm.nih.gov/pubmed/18036834
https://www.proquest.com/docview/1506740063
https://www.proquest.com/docview/70204961
https://pubmed.ncbi.nlm.nih.gov/PMC2665307
Volume 39
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