Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication

• Published in: Molecular cell Vol. 72; no. 2; pp. 239 - 249.e5
• Main Authors: Reverón-Gómez, Nazaret, González-Aguilera, Cristina, Stewart-Morgan, Kathleen R., Petryk, Nataliya, Flury, Valentin, Graziano, Simona, Johansen, Jens Vilstrup, Jakobsen, Janus Schou, Alabert, Constance, Groth, Anja
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.10.2018; Cell Press
• Subjects: cell cycle; ChOR-seq; chromatin replication; DNA; DNA replication; epigenetics; epigenome maintenance; H3K27me3; H3K4me3; histone modification; histone recycling; histones; landscapes; methylation; nucleosomes; post-translational modification; quantitative ChIP-seq; histone modification; cell cycle; ChOR-seq; H3K4me3; quantitative ChIP-seq; histone recycling; epigenome maintenance; epigenetics; chromatin replication; H3K27me3

Chromatin organization is disrupted genome-wide during DNA replication. On newly synthesized DNA, nucleosomes are assembled from new naive histones and old modified histones. It remains unknown whether the landscape of histone post-translational modifications (PTMs) is faithfully copied during DNA r...