Analysis of SARS-CoV-2 variants B.1.617: host tropism, proteolytic activation, cell-cell fusion, and neutralization sensitivity

• Published in: Emerging microbes & infections Vol. 11; no. 1; pp. 1024 - 1036
• Main Authors: Zhang, Li, Li, Qianqian, Wu, Jiajing, Yu, Yuanling, Zhang, Yue, Nie, Jianhui, Liang, Ziteng, Cui, Zhimin, Liu, Shuo, Wang, Haixin, Ding, Ruxia, Jiang, Fei, Li, Tao, Nie, Lingling, Lu, Qiong, Li, Jiayi, Qin, Lili, Jiang, Yinan, Shi, Yi, Xu, Wenbo, Huang, Weijin, Wang, Youchun
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Acquired immune deficiency syndrome; AIDS; Animals; Antibodies, Neutralizing; B.1.617; Cell Fusion; cell-cell fusion; Coronaviruses; COVID-19; delta; Humans; infectivity; Mice; Mutation; neutralization; Pandemics; SARS-CoV-2 - genetics; SARS-CoV-2 variants; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus; Viral Tropism; Viruses; cell–cell fusion; SARS-CoV-2 variants; delta; B.1.617; infectivity; neutralization

SARS-CoV-2 has caused the COVID-19 pandemic. B.1.617 variants (including Kappa and Delta) have been transmitted rapidly in India. The transmissibility, pathogenicity, and neutralization characteristics of these variants have received considerable interest. In this study, 22 pseudotyped viruses were...