CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin

• Published in: Immunity (Cambridge, Mass.) Vol. 46; no. 2; pp. 287 - 300
• Main Authors: Cheuk, Stanley, Schlums, Heinrich, Gallais Sérézal, Irène, Martini, Elisa, Chiang, Samuel C., Marquardt, Nicole, Gibbs, Anna, Detlofsson, Ebba, Introini, Andrea, Forkel, Marianne, Höög, Charlotte, Tjernlund, Annelie, Michaëlsson, Jakob, Folkersen, Lasse, Mjösberg, Jenny, Blomqvist, Lennart, Ehrström, Marcus, Ståhle, Mona, Bryceson, Yenan T., Eidsmo, Liv
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.02.2017; Elsevier Limited; Cell Press
• Subjects: Biopsy; CD49a; CD8-Positive T-Lymphocytes - immunology; Cell Separation; Councils; Cytotoxicity; Cytotoxicity, Immunologic - immunology; Deoxyribonucleic acid; DNA; Experiments; Flow Cytometry; granzyme B; Humans; IL-15; Immunologic Memory - immunology; immunopathology; Integrin alpha1 - biosynthesis; Integrin alpha1 - immunology; Localization; Lymphocyte Activation - immunology; Lymphocytes; Microscopy, Confocal; perforin; Psoriasis; Psoriasis - immunology; Skin; Skin - immunology; T cell receptors; T-Lymphocyte Subsets - immunology; tissue resident T cells; Vitiligo; Vitiligo - immunology; granzyme B; perforin; immunopathology; CD49a; tissue resident T cells; psoriasis; vitiligo; IL-15; Skin; cytotoxicity

Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that differentiates CD8+ Trm cells on a compartmental and functional basis. In human skin epithelia, CD8+CD49a+ Trm cells produced interferon...