Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function
Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related to cancer therapy, treatment for cardiovascular dysfunction, and suppression of inflammation. The molecular basis for PARP1 inhibitor functi...
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| Published in | Molecular cell Vol. 58; no. 6; pp. 925 - 934 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
18.06.2015
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| Abstract | Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related to cancer therapy, treatment for cardiovascular dysfunction, and suppression of inflammation. The molecular basis for PARP1 inhibitor function is complex, and appears to depend on the dual roles of PARP1 in DNA damage repair and transcriptional regulation. Here, the mechanisms by which PARP-1 inhibitors elicit clinical response are discussed, and strategies for translating the preclinical elucidation of PARP-1 function into advances in disease management are reviewed.
Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have clinical impact in a number of disease settings. In this Perspective, the mechanisms by which PARP1 inhibitors elicit clinical response are discussed, and strategies for translating the preclinical elucidation of PARP1 function into advances in disease management are reviewed. |
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| AbstractList | Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related to cancer therapy, treatment for cardiovascular dysfunction, and suppression of inflammation. The molecular basis for PARP1 inhibitor function is complex, and appears to depend on the dual roles of PARP1 in DNA damage repair and transcriptional regulation. Here, the mechanisms by which PARP-1 inhibitors elicit clinical response are discussed, and strategies for translating the preclinical elucidation of PARP-1 function into advances in disease management are reviewed. Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have clinical impact in a number of disease settings, particularly as related to cancer therapy, treatment for cardiovascular dysfunction, and suppression of inflammation. The molecular basis for PARP1 inhibitor function is complex, and appears to depend on the dual roles of PARP1 in DNA damage repair and transcriptional regulation. Here, the mechanisms by which PARP-1 inhibitors elicit clinical response are discussed, and strategies for translating the preclinical elucidation of PARP-1 function into advances in disease management are reviewed. Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related to cancer therapy, treatment for cardiovascular dysfunction, and suppression of inflammation. The molecular basis for PARP1 inhibitor function is complex, and appears to depend on the dual roles of PARP1 in DNA damage repair and transcriptional regulation. Here, the mechanisms by which PARP-1 inhibitors elicit clinical response are discussed, and strategies for translating the preclinical elucidation of PARP-1 function into advances in disease management are reviewed. Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have clinical impact in a number of disease settings. In this Perspective, the mechanisms by which PARP1 inhibitors elicit clinical response are discussed, and strategies for translating the preclinical elucidation of PARP1 function into advances in disease management are reviewed. |
| Author | Rubin, Mark A. Knudsen, Karen E. Feng, Felix Y. de Bono, Johann S. |
| AuthorAffiliation | 4 Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107 8 Dept. of Radiation Oncology, Univ. of Michigan, Ann Arbor, Michigan, 48109 6 Institute for Precision Medicine of Weill Cornell Medical College and NewYork-Presbyterian Hospital, New York, NY; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY; Department of Urology, Weill Cornell Medical College, New York, NY; Meyer Cancer Center of Weill Cornell Medical College and NewYork-Presbyterian Hospital, New York, NY. 10021 9 Comprehensive Cancer Center, Univ. of Michigan, Ann Arbor, Michigan, 48109 1 Dept. of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107 7 Michigan Center for Translational Pathology, Univ. of Michigan, Ann Arbor, Michigan, 48109 3 Dept. of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107 5 Prostate Cancer Targeted Therapy Group, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK 2 Dep |
| AuthorAffiliation_xml | – name: 7 Michigan Center for Translational Pathology, Univ. of Michigan, Ann Arbor, Michigan, 48109 – name: 3 Dept. of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107 – name: 6 Institute for Precision Medicine of Weill Cornell Medical College and NewYork-Presbyterian Hospital, New York, NY; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY; Department of Urology, Weill Cornell Medical College, New York, NY; Meyer Cancer Center of Weill Cornell Medical College and NewYork-Presbyterian Hospital, New York, NY. 10021 – name: 8 Dept. of Radiation Oncology, Univ. of Michigan, Ann Arbor, Michigan, 48109 – name: 1 Dept. of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107 – name: 4 Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107 – name: 9 Comprehensive Cancer Center, Univ. of Michigan, Ann Arbor, Michigan, 48109 – name: 2 Dept. of Urology, Thomas Jefferson University, Philadelphia, PA, 19107 – name: 5 Prostate Cancer Targeted Therapy Group, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK |
| Author_xml | – sequence: 1 givenname: Felix Y. surname: Feng fullname: Feng, Felix Y. organization: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, 48109, USA – sequence: 2 givenname: Johann S. surname: de Bono fullname: de Bono, Johann S. organization: Prostate Cancer Targeted Therapy Group, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK – sequence: 3 givenname: Mark A. surname: Rubin fullname: Rubin, Mark A. organization: Institute for Precision Medicine of Weill Cornell Medical College and NewYork-Presbyterian Hospital; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College; Department of Urology, Weill Cornell Medical College; Meyer Cancer Center of Weill Cornell Medical College and New York-Presbyterian Hospital, New York, NY 10021, USA – sequence: 4 givenname: Karen E. surname: Knudsen fullname: Knudsen, Karen E. email: karen.knudsen@jefferson.edu organization: Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26091341$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1073/pnas.0906920106 10.1093/emboj/18.16.4446 10.1016/j.cell.2004.11.017 10.1126/science.1149250 10.1200/jco.2013.31.15_suppl.4013 10.1101/gad.9.5.509 10.1182/blood.V99.6.2241 10.1038/nrm3376 10.1038/emboj.2009.206 10.1111/febs.12358 10.1158/1078-0432.CCR-11-2890 10.1073/pnas.93.5.1753 10.1016/0921-8777(89)90012-8 10.1101/gad.183509.111 10.1016/j.febslet.2012.09.026 10.2741/4318 10.1016/S0140-6736(10)60893-8 10.1038/nmeth.2603 10.1158/0008-5472.CAN-13-3159 10.1038/nrclinonc.2014.163 10.3389/fonc.2013.00257 10.1016/j.mam.2013.01.005 10.1016/j.dnarep.2011.08.012 10.4161/cc.4.9.2031 10.1158/0008-5472.CAN-11-3417 10.1038/nature03445 10.1158/0008-5472.CAN-05-3050 10.1056/NEJMoa0900212 10.1016/j.ceb.2006.02.013 10.3389/fonc.2013.00301 10.1158/0008-5472.CAN-12-2753 10.1016/j.molcel.2010.08.014 10.1038/nsmb.1664 10.1038/ncb2593 10.1158/2159-8290.CD-12-0120 10.1515/BC.1999.118 10.1074/jbc.M109.023879 10.1084/jem.20082468 10.1016/j.mam.2013.01.006 10.1007/s11239-008-0230-1 10.1016/j.molcel.2014.01.005 10.1023/A:1006941016799 10.1158/0008-5472.CAN-06-0140 10.1038/nature10404 10.1016/j.ejca.2009.10.021 10.1158/2159-8290.CD-14-0358 10.1093/annonc/mdu438.20 10.1111/j.1432-1033.1980.tb04528.x 10.1016/j.yexcr.2014.07.003 10.1007/s00018-002-8527-2 10.1016/j.gde.2010.06.001 10.1016/j.cell.2015.05.001 10.1093/nar/gkl840 10.1016/S0140-6736(10)60892-6 10.1016/j.ccr.2011.04.010 10.1038/nature06420 10.1016/S1470-2045(14)70228-1 10.1016/j.tem.2014.11.003 10.1016/0009-2797(82)90062-X 10.1073/pnas.1209507110 10.1016/j.radonc.2009.06.024 10.1016/j.molcel.2010.12.006 10.1016/S0921-8777(00)00016-1 10.1056/NEJMoa1105535 10.1158/1541-7786.MCR-13-0672 10.1158/2159-8290.CD-13-0172 10.1042/bj3460641 10.1016/j.brainres.2011.05.069 10.1371/journal.pbio.0060252 10.1158/2159-8290.CD-13-0108 10.1200/JCO.2014.55.2984 10.1073/pnas.052712399 10.1038/83241 10.1074/jbc.M104666200 10.1038/nsmb.2523 10.1016/S1470-2045(14)71135-0 10.1016/j.molcel.2011.11.015 |
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| References | Li, Yu (bib40) 2014 Schiewer, Knudsen (bib65) 2014; 12 Bang, Al, Al (bib6) 2013; 31 Kameoka, Ota, Tetsuka, Tanaka, Itaya, Okamoto, Yoshihara (bib34) 2000; 346 Nduka, Skidmore, Shall (bib52) 1980; 105 Liu, Taverna, Whitacre, Chatterjee, Gerson (bib41) 1999; 5 Robu, Shah, Petitclerc, Brind’Amour, Kandan-Kulangara, Shah (bib61) 2013; 110 Sonnenblick, de Azambuja, Azim, Piccart (bib69) 2015; 12 Petesch, Lis (bib57) 2012; 45 Kraus, Hottiger (bib35) 2013; 34 Polkinghorn, Parker, Lee, Kass, Spratt, Iaquinta, Arora, Yen, Cai, Zheng (bib58) 2013; 3 Krishnakumar, Kraus (bib36) 2010; 39 O’Shaughnessy, Schwartzberg, Danso, Miller, Rugo, Neubauer, Robert, Hellerstedt, Saleh, Richards (bib53) 2014; 32 Patel, De Lorenzo, Flatten, Poirier, Kaufmann (bib56) 2012; 18 Curtin, Szabo (bib13) 2013; 34 Frizzell, Gamble, Berrocal, Zhang, Krishnakumar, Cen, Sauve, Kraus (bib17) 2009; 284 Liu, Kadyrov, Modrich (bib42) 2011; 10 Murai, Huang, Das, Renaud, Zhang, Doroshow, Ji, Takeda, Pommier (bib51) 2012; 72 Beck, Robert, Reina-San-Martin, Schreiber, Dantzer (bib8) 2014; 329 Gagné, Hendzel, Droit, Poirier (bib18) 2006; 18 Bai, Nagy, Fodor, Liaudet, Pacher (bib5) 2015; 26 Wang, Auer, Stingl, Berghammer, Haidacher, Schweiger, Wagner (bib77) 1995; 9 Ju, Solum, Song, Lee, Rose, Glass, Rosenfeld (bib32) 2004; 119 Krishnakumar, Gamble, Frizzell, Berrocal, Kininis, Kraus (bib37) 2008; 319 Prensner, Chen, Iyer, Cao, Ma, Han, Sahu, Malik, Wilder-Romans, Navone (bib59) 2014; 74 Slade, Dunstan, Barkauskaite, Weston, Lafite, Dixon, Ahel, Leys, Ahel (bib68) 2011; 477 Fong, Boss, Yap, Tutt, Wu, Mergui-Roelvink, Mortimer, Swaisland, Lau, O’Connor (bib16) 2009; 361 Masutani, Nozaki, Nishiyama, Shimokawa, Tachi, Suzuki, Nakagama, Wakabayashi, Sugimura (bib46) 1999; 193 Tentori, Leonetti, Scarsella, d’Amati, Portarena, Zupi, Bonmassar, Graziani (bib72) 2002; 99 Timinszky, Till, Hassa, Hothorn, Kustatscher, Nijmeijer, Colombelli, Altmeyer, Stelzer, Scheffzek (bib74) 2009; 16 Virág, Jagtap, Szabó, Mabley, Liaudet, Marton, Hoyt, Murthy, Salzman, Southan, Szabó (bib76) 2001; 7 Alvarez-Gonzalez, Althaus (bib2) 1989; 218 Goodwin, Knudsen (bib21) 2014; 4 Hassa, Hottiger (bib25) 1999; 380 Bai, Virág (bib4) 2012; 586 Thomas, Kotova, Andrake, Adolf-Bryfogle, Glaser, Regnard, Tulin (bib73) 2014; 53 Goodwin, Schiewer, Dean, Schrecengost, de Leeuw, Han, Ma, Den, Dicker, Feng, Knudsen (bib22) 2013; 3 Durrant, Boyle (bib14) 1982; 38 Ying, Hamdy, Helleday (bib79) 2012; 72 Chang, Alvarez-Gonzalez (bib12) 2001; 276 Hassa, Hottiger (bib26) 2002; 59 Morrow, Brickman, Murphy, Baran, Krakover, Dauerman, Kumar, Slomowitz, Grip, McCabe, Salzman (bib50) 2009; 27 Steffen, Brody, Armen, Pascal (bib70) 2013; 3 Robinson, Van Allen, Wu, Schultz, Lonigro, Mosquera, Montgomery, Taplin, Pritchard, Attard (bib81) 2015; 161 Iliakis (bib29) 2009; 92 Ahel, Ahel, Matsusaka, Clark, Pines, Boulton, West (bib1) 2008; 451 Jwa, Chang (bib33) 2012; 14 Shall, de Murcia (bib67) 2000; 460 Ledermann, Harter, Gourley, Friedlander, Vergote, Rustin, Scott, Meier, Shapira-Frommer, Safra (bib39) 2014; 15 Robert, Dantzer, Reina-San-Martin (bib60) 2009; 206 Horton, Wilson (bib28) 2013; 3 Barkauskaite, Jankevicius, Ladurner, Ahel, Timinszky (bib7) 2013; 280 Ji, Tulin (bib31) 2010; 20 Gibson, Kraus (bib19) 2012; 13 Jankevicius, Hassler, Golia, Rybin, Zacharias, Timinszky, Ladurner (bib30) 2013; 20 Helleday, Bryant, Schultz (bib27) 2005; 4 Golia, Singh, Timinszky (bib20) 2015; 20 Matsuura, Egi, Yuki, Horikawa, Satoh, Akira (bib48) 2011; 1410 Oliver, Ménissier-de Murcia, Nacci, Decker, Andriantsitohaina, Muller, de la Rubia, Stoclet, de Murcia (bib54) 1999; 18 Ledermann, Harter, Gourley, Friedlander, Vergote, Rustin, Scott, Meier, Shapira-Frommer, Safra (bib38) 2012; 366 Wang, Wu, Wu, Rosidi, Zhang, Wang, Iliakis (bib78) 2006; 34 Audeh, Carmichael, Penson, Friedlander, Powell, Bell-McGuinn, Scott, Weitzel, Oaknin, Loman (bib3) 2010; 376 Tutt, Robson, Garber, Domchek, Audeh, Weitzel, Friedlander, Arun, Loman, Schmutzler (bib75) 2010; 376 Farmer, McCabe, Lord, Tutt, Johnson, Richardson, Santarosa, Dillon, Hickson, Knights (bib15) 2005; 434 Lupo, Trusolino (bib44) 2014; 1846 Ha, Hester, Snyder (bib24) 2002; 99 Zhang, Wang, Ding, Yu (bib80) 2013; 10 Oza, Cibula, Benzaquen, Poole, Mathijssen, Sonke, Colombo, Špaček, Vuylsteke, Hirte (bib55) 2015; 16 Mateo, Hall, Sandhu, Omlin, Miranda, Carreira, Goodall, Gillman, Mossop, Ralph (bib47) 2014; 25 Rulten, Fisher, Robert, Zuma, Rouleau, Ju, Poirier, Reina-San-Martin, Caldecott (bib62) 2011; 41 McCabe, Turner, Lord, Kluzek, Bialkowska, Swift, Giavara, O’Connor, Tutt, Zdzienicka (bib49) 2006; 66 Sandhu, Yap, de Bono (bib64) 2010; 46 Schiewer, Goodwin, Han, Brenner, Augello, Dean, Liu, Planck, Ravindranathan, Chinnaiyan (bib66) 2012; 2 Brenner, Ateeq, Li, Yocum, Cao, Asangani, Patel, Wang, Liang, Yu (bib9) 2011; 19 Sala, La Rocca, Burgio, Kotova, Di Gesù, Collesano, Ingrassia, Tulin, Corona (bib63) 2008; 6 Gottschalk, Timinszky, Kong, Jin, Cai, Swanson, Washburn, Florens, Ladurner, Conaway, Conaway (bib23) 2009; 106 Martin-Oliva, Aguilar-Quesada, O’valle, Muñoz-Gámez, Martínez-Romero, García Del Moral, Ruiz de Almodóvar, Villuendas, Piris, Oliver (bib45) 2006; 66 Szabó, Zingarelli, O’Connor, Salzman (bib71) 1996; 93 Bryant, Petermann, Schultz, Jemth, Loseva, Issaeva, Johansson, Fernandez, McGlynn, Helleday (bib10) 2009; 28 Luo, Kraus (bib43) 2012; 26 Ying (10.1016/j.molcel.2015.04.016_bib79) 2012; 72 Bryant (10.1016/j.molcel.2015.04.016_bib10) 2009; 28 Bai (10.1016/j.molcel.2015.04.016_bib5) 2015; 26 Morrow (10.1016/j.molcel.2015.04.016_bib50) 2009; 27 Golia (10.1016/j.molcel.2015.04.016_bib20) 2015; 20 Ledermann (10.1016/j.molcel.2015.04.016_bib39) 2014; 15 Farmer (10.1016/j.molcel.2015.04.016_bib15) 2005; 434 Petesch (10.1016/j.molcel.2015.04.016_bib57) 2012; 45 Wang (10.1016/j.molcel.2015.04.016_bib77) 1995; 9 Mateo (10.1016/j.molcel.2015.04.016_bib47) 2014; 25 Gagné (10.1016/j.molcel.2015.04.016_bib18) 2006; 18 Martin-Oliva (10.1016/j.molcel.2015.04.016_bib45) 2006; 66 Chang (10.1016/j.molcel.2015.04.016_bib12) 2001; 276 Murai (10.1016/j.molcel.2015.04.016_bib51) 2012; 72 Iliakis (10.1016/j.molcel.2015.04.016_bib29) 2009; 92 Robu (10.1016/j.molcel.2015.04.016_bib61) 2013; 110 O’Shaughnessy (10.1016/j.molcel.2015.04.016_bib53) 2014; 32 Audeh (10.1016/j.molcel.2015.04.016_bib3) 2010; 376 Hassa (10.1016/j.molcel.2015.04.016_bib26) 2002; 59 Steffen (10.1016/j.molcel.2015.04.016_bib70) 2013; 3 Tentori (10.1016/j.molcel.2015.04.016_bib72) 2002; 99 Li (10.1016/j.molcel.2015.04.016_bib40) 2014 Beck (10.1016/j.molcel.2015.04.016_bib8) 2014; 329 Masutani (10.1016/j.molcel.2015.04.016_bib46) 1999; 193 Alvarez-Gonzalez (10.1016/j.molcel.2015.04.016_bib2) 1989; 218 Tutt (10.1016/j.molcel.2015.04.016_bib75) 2010; 376 Jwa (10.1016/j.molcel.2015.04.016_bib33) 2012; 14 Sala (10.1016/j.molcel.2015.04.016_bib63) 2008; 6 Sandhu (10.1016/j.molcel.2015.04.016_bib64) 2010; 46 Schiewer (10.1016/j.molcel.2015.04.016_bib65) 2014; 12 Ju (10.1016/j.molcel.2015.04.016_bib32) 2004; 119 Prensner (10.1016/j.molcel.2015.04.016_bib59) 2014; 74 Szabó (10.1016/j.molcel.2015.04.016_bib71) 1996; 93 Hassa (10.1016/j.molcel.2015.04.016_bib25) 1999; 380 Bang (10.1016/j.molcel.2015.04.016_bib6) 2013; 31 Goodwin (10.1016/j.molcel.2015.04.016_bib22) 2013; 3 Horton (10.1016/j.molcel.2015.04.016_bib28) 2013; 3 Brenner (10.1016/j.molcel.2015.04.016_bib9) 2011; 19 Polkinghorn (10.1016/j.molcel.2015.04.016_bib58) 2013; 3 Krishnakumar (10.1016/j.molcel.2015.04.016_bib36) 2010; 39 Matsuura (10.1016/j.molcel.2015.04.016_bib48) 2011; 1410 Rulten (10.1016/j.molcel.2015.04.016_bib62) 2011; 41 Ha (10.1016/j.molcel.2015.04.016_bib24) 2002; 99 Kraus (10.1016/j.molcel.2015.04.016_bib35) 2013; 34 Lupo (10.1016/j.molcel.2015.04.016_bib44) 2014; 1846 Fong (10.1016/j.molcel.2015.04.016_bib16) 2009; 361 Durrant (10.1016/j.molcel.2015.04.016_bib14) 1982; 38 Robert (10.1016/j.molcel.2015.04.016_bib60) 2009; 206 Virág (10.1016/j.molcel.2015.04.016_bib76) 2001; 7 Bai (10.1016/j.molcel.2015.04.016_bib4) 2012; 586 Oza (10.1016/j.molcel.2015.04.016_bib55) 2015; 16 McCabe (10.1016/j.molcel.2015.04.016_bib49) 2006; 66 Jankevicius (10.1016/j.molcel.2015.04.016_bib30) 2013; 20 Ledermann (10.1016/j.molcel.2015.04.016_bib38) 2012; 366 Thomas (10.1016/j.molcel.2015.04.016_bib73) 2014; 53 Oliver (10.1016/j.molcel.2015.04.016_bib54) 1999; 18 Curtin (10.1016/j.molcel.2015.04.016_bib13) 2013; 34 Zhang (10.1016/j.molcel.2015.04.016_bib80) 2013; 10 Robinson (10.1016/j.molcel.2015.04.016_bib81) 2015; 161 Gibson (10.1016/j.molcel.2015.04.016_bib19) 2012; 13 Krishnakumar (10.1016/j.molcel.2015.04.016_bib37) 2008; 319 Gottschalk (10.1016/j.molcel.2015.04.016_bib23) 2009; 106 Schiewer (10.1016/j.molcel.2015.04.016_bib66) 2012; 2 Patel (10.1016/j.molcel.2015.04.016_bib56) 2012; 18 Slade (10.1016/j.molcel.2015.04.016_bib68) 2011; 477 Timinszky (10.1016/j.molcel.2015.04.016_bib74) 2009; 16 Helleday (10.1016/j.molcel.2015.04.016_bib27) 2005; 4 Liu (10.1016/j.molcel.2015.04.016_bib42) 2011; 10 Barkauskaite (10.1016/j.molcel.2015.04.016_bib7) 2013; 280 Ahel (10.1016/j.molcel.2015.04.016_bib1) 2008; 451 Goodwin (10.1016/j.molcel.2015.04.016_bib21) 2014; 4 Ji (10.1016/j.molcel.2015.04.016_bib31) 2010; 20 Kameoka (10.1016/j.molcel.2015.04.016_bib34) 2000; 346 Shall (10.1016/j.molcel.2015.04.016_bib67) 2000; 460 Liu (10.1016/j.molcel.2015.04.016_bib41) 1999; 5 Luo (10.1016/j.molcel.2015.04.016_bib43) 2012; 26 Sonnenblick (10.1016/j.molcel.2015.04.016_bib69) 2015; 12 Frizzell (10.1016/j.molcel.2015.04.016_bib17) 2009; 284 Wang (10.1016/j.molcel.2015.04.016_bib78) 2006; 34 Nduka (10.1016/j.molcel.2015.04.016_bib52) 1980; 105 21892188 - Nature. 2011 Sep 29;477(7366):616-20 20832725 - Mol Cell. 2010 Sep 10;39(5):736-49 25553460 - Front Biosci (Landmark Ed). 2015;20:440-57 21211721 - Mol Cell. 2011 Jan 7;41(1):33-45 25349301 - J Clin Oncol. 2014 Dec 1;32(34):3840-7 7698643 - Genes Dev. 1995 Mar 1;9(5):509-20 23022557 - FEBS Lett. 2012 Nov 2;586(21):3771-7 18258916 - Science. 2008 Feb 8;319(5864):819-21 23474712 - Nat Struct Mol Biol. 2013 Apr;20(4):508-14 23711178 - FEBS J. 2013 Aug;280(15):3491-507 10856830 - Mutat Res. 2000 Jun 30;460(1):1-15 25220415 - Oncogene. 2015 Jun;34(26):3349-56 10537360 - Clin Cancer Res. 1999 Oct;5(10):2908-17 18535785 - J Thromb Thrombolysis. 2009 May;27(4):359-64 18922045 - PLoS Biol. 2008 Oct 14;6(10):e252 20591646 - Curr Opin Genet Dev. 2010 Oct;20(5):512-8 11577079 - J Biol Chem. 2001 Dec 14;276(50):47664-70 12440774 - Cell Mol Life Sci. 2002 Sep;59(9):1534-53 15607978 - Cell. 2004 Dec 17;119(6):815-29 25497347 - Trends Endocrinol Metab. 2015 Feb;26(2):75-83 23370117 - Mol Aspects Med. 2013 Dec;34(6):1217-56 19553641 - N Engl J Med. 2009 Jul 9;361(2):123-34 10494847 - Biol Chem. 1999 Jul-Aug;380(7-8):953-9 15829967 - Nature. 2005 Apr 14;434(7035):917-21 23103912 - Nat Cell Biol. 2012 Nov;14(11):1223-30 22447567 - Cancer Res. 2012 Jun 1;72(11):2814-21 19666485 - Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13770-4 24392349 - Front Oncol. 2013 Dec 20;3:301 24882434 - Lancet Oncol. 2014 Jul;15(8):852-61 23357755 - Mol Aspects Med. 2013 Dec;34(6):1109-23 24137565 - Front Oncol. 2013 Sep 30;3:257 11135624 - Nat Med. 2001 Jan;7(1):108-13 24473064 - Cancer Res. 2014 Mar 15;74(6):1651-60 21945626 - DNA Repair (Amst). 2011 Nov 10;10(11):1145-53 2770765 - Mutat Res. 1989 Sep;218(2):67-74 19680243 - Nat Struct Mol Biol. 2009 Sep;16(9):923-9 16740713 - Cancer Res. 2006 Jun 1;66(11):5744-56 19812418 - J Biol Chem. 2009 Dec 4;284(49):33926-38 25017100 - Exp Cell Res. 2014 Nov 15;329(1):18-25 16123586 - Cell Cycle. 2005 Sep;4(9):1176-8 19604590 - Radiother Oncol. 2009 Sep;92(3):310-5 6277522 - Chem Biol Interact. 1982 Feb;38(3):325-38 25286972 - Nat Rev Clin Oncol. 2015 Jan;12(1):27-41 23118055 - Cancer Res. 2012 Nov 1;72(21):5588-99 17088286 - Nucleic Acids Res. 2006;34(21):6170-82 24508391 - Mol Cell. 2014 Mar 6;53(5):831-42 10449410 - EMBO J. 1999 Aug 16;18(16):4446-54 21575865 - Cancer Cell. 2011 May 17;19(5):664-78 10331651 - Mol Cell Biochem. 1999 Mar;193(1-2):149-52 25168287 - Cancer Discov. 2014 Oct;4(10):1126-39 23319653 - Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1658-63 16516457 - Curr Opin Cell Biol. 2006 Apr;18(2):145-51 6245884 - Eur J Biochem. 1980 Apr;105(3):525-30 11854472 - Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3270-5 23955771 - Nat Methods. 2013 Oct;10(10):981-4 10698690 - Biochem J. 2000 Mar 15;346 Pt 3:641-9 14019961 - Biochem Biophys Res Commun. 1963 Apr 2;11:39-43 22993403 - Cancer Discov. 2012 Dec;2(12):1134-49 20609468 - Lancet. 2010 Jul 24;376(9737):245-51 24027197 - Cancer Discov. 2013 Nov;3(11):1254-71 24916104 - Mol Cancer Res. 2014 Aug;12(8):1069-80 22713970 - Nat Rev Mol Cell Biol. 2012 Jul;13(7):411-24 16912188 - Cancer Res. 2006 Aug 15;66(16):8109-15 25026313 - Biochim Biophys Acta. 2014 Aug;1846(1):201-15 11877304 - Blood. 2002 Mar 15;99(6):2241-4 18172500 - Nature. 2008 Jan 3;451(7174):81-5 20609467 - Lancet. 2010 Jul 24;376(9737):235-44 22452356 - N Engl J Med. 2012 Apr 12;366(15):1382-92 8700830 - Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1753-8 21741620 - Brain Res. 2011 Sep 2;1410:122-31 22178397 - Mol Cell. 2012 Jan 13;45(1):64-74 24027196 - Cancer Discov. 2013 Nov;3(11):1245-53 25481791 - Lancet Oncol. 2015 Jan;16(1):87-97 19364882 - J Exp Med. 2009 May 11;206(5):1047-56 26282658 - J Clin Oncol. 2015 Nov 20;33(33):3858-65 19629035 - EMBO J. 2009 Sep 2;28(17):2601-15 19926276 - Eur J Cancer. 2010 Jan;46(1):9-20 22391446 - Genes Dev. 2012 Mar 1;26(5):417-32 22291137 - Clin Cancer Res. 2012 Mar 15;18(6):1655-62 |
| References_xml | – volume: 15 start-page: 852 year: 2014 end-page: 861 ident: bib39 article-title: Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial publication-title: Lancet Oncol. – volume: 72 start-page: 2814 year: 2012 end-page: 2821 ident: bib79 article-title: Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1 publication-title: Cancer Res. – volume: 32 start-page: 3840 year: 2014 end-page: 3847 ident: bib53 article-title: Phase III study of iniparib plus gemcitabine and carboplatin versus gemcitabine and carboplatin in patients with metastatic triple-negative breast cancer publication-title: J. Clin. Oncol. – volume: 31 start-page: a4013 year: 2013 ident: bib6 article-title: Olaparib plus paclitaxel in patients with recurrent or metastatic gastric cancer: a randomized, double-blind phase II study publication-title: J. Clin. Oncol. – volume: 45 start-page: 64 year: 2012 end-page: 74 ident: bib57 article-title: Activator-induced spread of poly(ADP-ribose) polymerase promotes nucleosome loss at Hsp70 publication-title: Mol. Cell – volume: 329 start-page: 18 year: 2014 end-page: 25 ident: bib8 article-title: Poly(ADP-ribose) polymerases in double-strand break repair: focus on PARP1, PARP2 and PARP3 publication-title: Exp. Cell Res. – volume: 119 start-page: 815 year: 2004 end-page: 829 ident: bib32 article-title: Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway publication-title: Cell – volume: 105 start-page: 525 year: 1980 end-page: 530 ident: bib52 article-title: The enhancement of cytotoxicity of N-methyl-N-nitrosourea and of gamma-radiation by inhibitors of poly(ADP-ribose) polymerase publication-title: Eur. J. Biochem. – volume: 39 start-page: 736 year: 2010 end-page: 749 ident: bib36 article-title: PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway publication-title: Mol. Cell – volume: 1410 start-page: 122 year: 2011 end-page: 131 ident: bib48 article-title: MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model publication-title: Brain Res. – volume: 16 start-page: 87 year: 2015 end-page: 97 ident: bib55 article-title: Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial publication-title: Lancet Oncol. – volume: 9 start-page: 509 year: 1995 end-page: 520 ident: bib77 article-title: Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease publication-title: Genes Dev. – volume: 10 start-page: 1145 year: 2011 end-page: 1153 ident: bib42 article-title: PARP-1 enhances the mismatch-dependence of 5′-directed excision in human mismatch repair in vitro publication-title: DNA Repair (Amst.) – volume: 361 start-page: 123 year: 2009 end-page: 134 ident: bib16 article-title: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers publication-title: N. Engl. J. Med. – volume: 206 start-page: 1047 year: 2009 end-page: 1056 ident: bib60 article-title: Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination publication-title: J. Exp. Med. – volume: 3 start-page: 1254 year: 2013 end-page: 1271 ident: bib22 article-title: A hormone-DNA repair circuit governs the response to genotoxic insult publication-title: Cancer Discov – volume: 280 start-page: 3491 year: 2013 end-page: 3507 ident: bib7 article-title: The recognition and removal of cellular poly(ADP-ribose) signals publication-title: FEBS J. – volume: 53 start-page: 831 year: 2014 end-page: 842 ident: bib73 article-title: Kinase-mediated changes in nucleosome conformation trigger chromatin decondensation via poly(ADP-ribosyl)ation publication-title: Mol. Cell – volume: 19 start-page: 664 year: 2011 end-page: 678 ident: bib9 article-title: Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer publication-title: Cancer Cell – volume: 366 start-page: 1382 year: 2012 end-page: 1392 ident: bib38 article-title: Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer publication-title: N. Engl. J. Med. – volume: 26 start-page: 417 year: 2012 end-page: 432 ident: bib43 article-title: On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1 publication-title: Genes Dev. – volume: 3 start-page: 301 year: 2013 ident: bib70 article-title: Structural Implications for Selective Targeting of PARPs publication-title: Front Oncol – volume: 18 start-page: 145 year: 2006 end-page: 151 ident: bib18 article-title: The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives publication-title: Curr. Opin. Cell Biol. – volume: 4 start-page: 1176 year: 2005 end-page: 1178 ident: bib27 article-title: Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy publication-title: Cell Cycle – volume: 319 start-page: 819 year: 2008 end-page: 821 ident: bib37 article-title: Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes publication-title: Science – volume: 20 start-page: 512 year: 2010 end-page: 518 ident: bib31 article-title: The roles of PARP1 in gene control and cell differentiation publication-title: Curr. Opin. Genet. Dev. – volume: 66 start-page: 5744 year: 2006 end-page: 5756 ident: bib45 article-title: Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis publication-title: Cancer Res. – volume: 66 start-page: 8109 year: 2006 end-page: 8115 ident: bib49 article-title: Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition publication-title: Cancer Res. – volume: 18 start-page: 1655 year: 2012 end-page: 1662 ident: bib56 article-title: Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro publication-title: Clin. Cancer Res. – volume: 59 start-page: 1534 year: 2002 end-page: 1553 ident: bib26 article-title: The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders publication-title: Cell. Mol. Life Sci. – volume: 41 start-page: 33 year: 2011 end-page: 45 ident: bib62 article-title: PARP-3 and APLF function together to accelerate nonhomologous end-joining publication-title: Mol. Cell – volume: 106 start-page: 13770 year: 2009 end-page: 13774 ident: bib23 article-title: Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler publication-title: Proc. Natl. Acad. Sci. USA – volume: 38 start-page: 325 year: 1982 end-page: 338 ident: bib14 article-title: Potentiation of cell killing by inhibitors of poly(ADP-ribose) polymerase in four rodent cell lines exposed to N-methyl-N-nitrosourea or UV light publication-title: Chem. Biol. Interact. – volume: 14 start-page: 1223 year: 2012 end-page: 1230 ident: bib33 article-title: PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response publication-title: Nat. Cell Biol. – volume: 346 start-page: 641 year: 2000 end-page: 649 ident: bib34 article-title: Evidence for regulation of NF-kappaB by poly(ADP-ribose) polymerase publication-title: Biochem. J. – volume: 7 start-page: 108 year: 2001 end-page: 113 ident: bib76 article-title: Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation publication-title: Nat. Med. – volume: 376 start-page: 235 year: 2010 end-page: 244 ident: bib75 article-title: Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial publication-title: Lancet – volume: 218 start-page: 67 year: 1989 end-page: 74 ident: bib2 article-title: Poly(ADP-ribose) catabolism in mammalian cells exposed to DNA-damaging agents publication-title: Mutat. Res. – volume: 27 start-page: 359 year: 2009 end-page: 364 ident: bib50 article-title: A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial publication-title: J. Thromb. Thrombolysis – volume: 26 start-page: 75 year: 2015 end-page: 83 ident: bib5 article-title: Poly(ADP-ribose) polymerases as modulators of mitochondrial activity publication-title: Trends Endocrinol. Metab. – volume: 5 start-page: 2908 year: 1999 end-page: 2917 ident: bib41 article-title: Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents publication-title: Clin. Cancer Res. – volume: 93 start-page: 1753 year: 1996 end-page: 1758 ident: bib71 article-title: DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite publication-title: Proc. Natl. Acad. Sci. USA – volume: 28 start-page: 2601 year: 2009 end-page: 2615 ident: bib10 article-title: PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination publication-title: EMBO J. – volume: 72 start-page: 5588 year: 2012 end-page: 5599 ident: bib51 article-title: Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors publication-title: Cancer Res. – volume: 20 start-page: 508 year: 2013 end-page: 514 ident: bib30 article-title: A family of macrodomain proteins reverses cellular mono-ADP-ribosylation publication-title: Nat. Struct. Mol. Biol. – volume: 18 start-page: 4446 year: 1999 end-page: 4454 ident: bib54 article-title: Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice publication-title: EMBO J. – volume: 99 start-page: 2241 year: 2002 end-page: 2244 ident: bib72 article-title: Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site publication-title: Blood – volume: 16 start-page: 923 year: 2009 end-page: 929 ident: bib74 article-title: A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation publication-title: Nat. Struct. Mol. Biol. – volume: 3 start-page: 257 year: 2013 ident: bib28 article-title: Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity publication-title: Front Oncol – year: 2014 ident: bib40 article-title: The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy publication-title: Oncogene – volume: 92 start-page: 310 year: 2009 end-page: 315 ident: bib29 article-title: Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence publication-title: Radiother. Oncol. – volume: 376 start-page: 245 year: 2010 end-page: 251 ident: bib3 article-title: Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial publication-title: Lancet – volume: 13 start-page: 411 year: 2012 end-page: 424 ident: bib19 article-title: New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs publication-title: Nat. Rev. Mol. Cell Biol. – volume: 284 start-page: 33926 year: 2009 end-page: 33938 ident: bib17 article-title: Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells publication-title: J. Biol. Chem. – volume: 25 start-page: 1 year: 2014 end-page: 41 ident: bib47 article-title: Antitumour activity of the PARP inhibitor olaparib in unselected sporadic castration-resistant prostate cancer (CRPC) in the TOPARP trial publication-title: Annals of oncology: official journal of the European Society for Medical Oncology / ESMO – volume: 451 start-page: 81 year: 2008 end-page: 85 ident: bib1 article-title: Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins publication-title: Nature – volume: 460 start-page: 1 year: 2000 end-page: 15 ident: bib67 article-title: Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? publication-title: Mutat. Res. – volume: 34 start-page: 6170 year: 2006 end-page: 6182 ident: bib78 article-title: PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways publication-title: Nucleic Acids Res. – volume: 276 start-page: 47664 year: 2001 end-page: 47670 ident: bib12 article-title: The sequence-specific DNA binding of NF-kappa B is reversibly regulated by the automodification reaction of poly (ADP-ribose) polymerase 1 publication-title: J. Biol. Chem. – volume: 2 start-page: 1134 year: 2012 end-page: 1149 ident: bib66 article-title: Dual roles of PARP-1 promote cancer growth and progression publication-title: Cancer Discov – volume: 586 start-page: 3771 year: 2012 end-page: 3777 ident: bib4 article-title: Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes publication-title: FEBS Lett. – volume: 12 start-page: 1069 year: 2014 end-page: 1080 ident: bib65 article-title: Transcriptional roles of PARP1 in cancer publication-title: Mol. Cancer Res. – volume: 12 start-page: 27 year: 2015 end-page: 41 ident: bib69 article-title: An update on PARP inhibitors—moving to the adjuvant setting publication-title: Nat. Rev. Clin. Oncol. – volume: 99 start-page: 3270 year: 2002 end-page: 3275 ident: bib24 article-title: Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia publication-title: Proc. Natl. Acad. Sci. USA – volume: 6 start-page: e252 year: 2008 ident: bib63 article-title: The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation publication-title: PLoS Biol. – volume: 46 start-page: 9 year: 2010 end-page: 20 ident: bib64 article-title: Poly(ADP-ribose) polymerase inhibitors in cancer treatment: a clinical perspective publication-title: Eur. J. Cancer – volume: 3 start-page: 1245 year: 2013 end-page: 1253 ident: bib58 article-title: Androgen receptor signaling regulates DNA repair in prostate cancers publication-title: Cancer Discov – volume: 10 start-page: 981 year: 2013 end-page: 984 ident: bib80 article-title: Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome publication-title: Nat. Methods – volume: 161 start-page: 1215 year: 2015 end-page: 1228 ident: bib81 article-title: Integrative clinical genomics of advanced prostate cancer publication-title: Cell – volume: 193 start-page: 149 year: 1999 end-page: 152 ident: bib46 article-title: Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-disruption study in mice publication-title: Mol. Cell. Biochem. – volume: 1846 start-page: 201 year: 2014 end-page: 215 ident: bib44 article-title: Inhibition of poly(ADP-ribosyl)ation in cancer: old and new paradigms revisited publication-title: Biochim. Biophys. Acta – volume: 434 start-page: 917 year: 2005 end-page: 921 ident: bib15 article-title: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy publication-title: Nature – volume: 20 start-page: 440 year: 2015 end-page: 457 ident: bib20 article-title: Poly-ADP-ribosylation signaling during DNA damage repair publication-title: Front Biosci (Landmark Ed) – volume: 380 start-page: 953 year: 1999 end-page: 959 ident: bib25 article-title: A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation publication-title: Biol. Chem. – volume: 34 start-page: 1109 year: 2013 end-page: 1123 ident: bib35 article-title: PARP-1 and gene regulation: progress and puzzles publication-title: Mol. Aspects Med. – volume: 74 start-page: 1651 year: 2014 end-page: 1660 ident: bib59 article-title: PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer publication-title: Cancer Res. – volume: 110 start-page: 1658 year: 2013 end-page: 1663 ident: bib61 article-title: Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair publication-title: Proc. Natl. Acad. Sci. USA – volume: 4 start-page: 1126 year: 2014 end-page: 1139 ident: bib21 article-title: Beyond DNA repair: DNA-PK function in cancer publication-title: Cancer Discov – volume: 477 start-page: 616 year: 2011 end-page: 620 ident: bib68 article-title: The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase publication-title: Nature – volume: 34 start-page: 1217 year: 2013 end-page: 1256 ident: bib13 article-title: Therapeutic applications of PARP inhibitors: anticancer therapy and beyond publication-title: Mol. Aspects Med. – year: 2014 ident: 10.1016/j.molcel.2015.04.016_bib40 article-title: The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy publication-title: Oncogene – volume: 106 start-page: 13770 year: 2009 ident: 10.1016/j.molcel.2015.04.016_bib23 article-title: Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0906920106 – volume: 18 start-page: 4446 year: 1999 ident: 10.1016/j.molcel.2015.04.016_bib54 article-title: Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice publication-title: EMBO J. doi: 10.1093/emboj/18.16.4446 – volume: 119 start-page: 815 year: 2004 ident: 10.1016/j.molcel.2015.04.016_bib32 article-title: Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway publication-title: Cell doi: 10.1016/j.cell.2004.11.017 – volume: 319 start-page: 819 year: 2008 ident: 10.1016/j.molcel.2015.04.016_bib37 article-title: Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes publication-title: Science doi: 10.1126/science.1149250 – volume: 31 start-page: a4013 year: 2013 ident: 10.1016/j.molcel.2015.04.016_bib6 article-title: Olaparib plus paclitaxel in patients with recurrent or metastatic gastric cancer: a randomized, double-blind phase II study publication-title: J. Clin. Oncol. doi: 10.1200/jco.2013.31.15_suppl.4013 – volume: 9 start-page: 509 year: 1995 ident: 10.1016/j.molcel.2015.04.016_bib77 article-title: Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease publication-title: Genes Dev. doi: 10.1101/gad.9.5.509 – volume: 99 start-page: 2241 year: 2002 ident: 10.1016/j.molcel.2015.04.016_bib72 article-title: Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site publication-title: Blood doi: 10.1182/blood.V99.6.2241 – volume: 13 start-page: 411 year: 2012 ident: 10.1016/j.molcel.2015.04.016_bib19 article-title: New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3376 – volume: 28 start-page: 2601 year: 2009 ident: 10.1016/j.molcel.2015.04.016_bib10 article-title: PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination publication-title: EMBO J. doi: 10.1038/emboj.2009.206 – volume: 5 start-page: 2908 year: 1999 ident: 10.1016/j.molcel.2015.04.016_bib41 article-title: Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents publication-title: Clin. Cancer Res. – volume: 280 start-page: 3491 year: 2013 ident: 10.1016/j.molcel.2015.04.016_bib7 article-title: The recognition and removal of cellular poly(ADP-ribose) signals publication-title: FEBS J. doi: 10.1111/febs.12358 – volume: 18 start-page: 1655 year: 2012 ident: 10.1016/j.molcel.2015.04.016_bib56 article-title: Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-11-2890 – volume: 93 start-page: 1753 year: 1996 ident: 10.1016/j.molcel.2015.04.016_bib71 article-title: DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.93.5.1753 – volume: 218 start-page: 67 year: 1989 ident: 10.1016/j.molcel.2015.04.016_bib2 article-title: Poly(ADP-ribose) catabolism in mammalian cells exposed to DNA-damaging agents publication-title: Mutat. Res. doi: 10.1016/0921-8777(89)90012-8 – volume: 26 start-page: 417 year: 2012 ident: 10.1016/j.molcel.2015.04.016_bib43 article-title: On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1 publication-title: Genes Dev. doi: 10.1101/gad.183509.111 – volume: 586 start-page: 3771 year: 2012 ident: 10.1016/j.molcel.2015.04.016_bib4 article-title: Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes publication-title: FEBS Lett. doi: 10.1016/j.febslet.2012.09.026 – volume: 20 start-page: 440 year: 2015 ident: 10.1016/j.molcel.2015.04.016_bib20 article-title: Poly-ADP-ribosylation signaling during DNA damage repair publication-title: Front Biosci (Landmark Ed) doi: 10.2741/4318 – volume: 376 start-page: 245 year: 2010 ident: 10.1016/j.molcel.2015.04.016_bib3 article-title: Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial publication-title: Lancet doi: 10.1016/S0140-6736(10)60893-8 – volume: 10 start-page: 981 year: 2013 ident: 10.1016/j.molcel.2015.04.016_bib80 article-title: Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome publication-title: Nat. Methods doi: 10.1038/nmeth.2603 – volume: 74 start-page: 1651 year: 2014 ident: 10.1016/j.molcel.2015.04.016_bib59 article-title: PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-13-3159 – volume: 12 start-page: 27 year: 2015 ident: 10.1016/j.molcel.2015.04.016_bib69 article-title: An update on PARP inhibitors—moving to the adjuvant setting publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/nrclinonc.2014.163 – volume: 3 start-page: 257 year: 2013 ident: 10.1016/j.molcel.2015.04.016_bib28 article-title: Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity publication-title: Front Oncol doi: 10.3389/fonc.2013.00257 – volume: 34 start-page: 1109 year: 2013 ident: 10.1016/j.molcel.2015.04.016_bib35 article-title: PARP-1 and gene regulation: progress and puzzles publication-title: Mol. Aspects Med. doi: 10.1016/j.mam.2013.01.005 – volume: 10 start-page: 1145 year: 2011 ident: 10.1016/j.molcel.2015.04.016_bib42 article-title: PARP-1 enhances the mismatch-dependence of 5′-directed excision in human mismatch repair in vitro publication-title: DNA Repair (Amst.) doi: 10.1016/j.dnarep.2011.08.012 – volume: 4 start-page: 1176 year: 2005 ident: 10.1016/j.molcel.2015.04.016_bib27 article-title: Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy publication-title: Cell Cycle doi: 10.4161/cc.4.9.2031 – volume: 72 start-page: 2814 year: 2012 ident: 10.1016/j.molcel.2015.04.016_bib79 article-title: Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-11-3417 – volume: 434 start-page: 917 year: 2005 ident: 10.1016/j.molcel.2015.04.016_bib15 article-title: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy publication-title: Nature doi: 10.1038/nature03445 – volume: 66 start-page: 5744 year: 2006 ident: 10.1016/j.molcel.2015.04.016_bib45 article-title: Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-05-3050 – volume: 361 start-page: 123 year: 2009 ident: 10.1016/j.molcel.2015.04.016_bib16 article-title: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0900212 – volume: 18 start-page: 145 year: 2006 ident: 10.1016/j.molcel.2015.04.016_bib18 article-title: The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2006.02.013 – volume: 3 start-page: 301 year: 2013 ident: 10.1016/j.molcel.2015.04.016_bib70 article-title: Structural Implications for Selective Targeting of PARPs publication-title: Front Oncol doi: 10.3389/fonc.2013.00301 – volume: 72 start-page: 5588 year: 2012 ident: 10.1016/j.molcel.2015.04.016_bib51 article-title: Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-12-2753 – volume: 39 start-page: 736 year: 2010 ident: 10.1016/j.molcel.2015.04.016_bib36 article-title: PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.08.014 – volume: 16 start-page: 923 year: 2009 ident: 10.1016/j.molcel.2015.04.016_bib74 article-title: A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.1664 – volume: 14 start-page: 1223 year: 2012 ident: 10.1016/j.molcel.2015.04.016_bib33 article-title: PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response publication-title: Nat. Cell Biol. doi: 10.1038/ncb2593 – volume: 2 start-page: 1134 year: 2012 ident: 10.1016/j.molcel.2015.04.016_bib66 article-title: Dual roles of PARP-1 promote cancer growth and progression publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-12-0120 – volume: 380 start-page: 953 year: 1999 ident: 10.1016/j.molcel.2015.04.016_bib25 article-title: A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation publication-title: Biol. Chem. doi: 10.1515/BC.1999.118 – volume: 284 start-page: 33926 year: 2009 ident: 10.1016/j.molcel.2015.04.016_bib17 article-title: Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.023879 – volume: 206 start-page: 1047 year: 2009 ident: 10.1016/j.molcel.2015.04.016_bib60 article-title: Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination publication-title: J. Exp. Med. doi: 10.1084/jem.20082468 – volume: 34 start-page: 1217 year: 2013 ident: 10.1016/j.molcel.2015.04.016_bib13 article-title: Therapeutic applications of PARP inhibitors: anticancer therapy and beyond publication-title: Mol. Aspects Med. doi: 10.1016/j.mam.2013.01.006 – volume: 27 start-page: 359 year: 2009 ident: 10.1016/j.molcel.2015.04.016_bib50 publication-title: J. Thromb. Thrombolysis doi: 10.1007/s11239-008-0230-1 – volume: 53 start-page: 831 year: 2014 ident: 10.1016/j.molcel.2015.04.016_bib73 article-title: Kinase-mediated changes in nucleosome conformation trigger chromatin decondensation via poly(ADP-ribosyl)ation publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.01.005 – volume: 193 start-page: 149 year: 1999 ident: 10.1016/j.molcel.2015.04.016_bib46 article-title: Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-disruption study in mice publication-title: Mol. Cell. Biochem. doi: 10.1023/A:1006941016799 – volume: 66 start-page: 8109 year: 2006 ident: 10.1016/j.molcel.2015.04.016_bib49 article-title: Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-06-0140 – volume: 477 start-page: 616 year: 2011 ident: 10.1016/j.molcel.2015.04.016_bib68 article-title: The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase publication-title: Nature doi: 10.1038/nature10404 – volume: 46 start-page: 9 year: 2010 ident: 10.1016/j.molcel.2015.04.016_bib64 article-title: Poly(ADP-ribose) polymerase inhibitors in cancer treatment: a clinical perspective publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2009.10.021 – volume: 4 start-page: 1126 year: 2014 ident: 10.1016/j.molcel.2015.04.016_bib21 article-title: Beyond DNA repair: DNA-PK function in cancer publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-14-0358 – volume: 25 start-page: 1 year: 2014 ident: 10.1016/j.molcel.2015.04.016_bib47 article-title: Antitumour activity of the PARP inhibitor olaparib in unselected sporadic castration-resistant prostate cancer (CRPC) in the TOPARP trial publication-title: Annals of oncology: official journal of the European Society for Medical Oncology / ESMO doi: 10.1093/annonc/mdu438.20 – volume: 105 start-page: 525 year: 1980 ident: 10.1016/j.molcel.2015.04.016_bib52 article-title: The enhancement of cytotoxicity of N-methyl-N-nitrosourea and of gamma-radiation by inhibitors of poly(ADP-ribose) polymerase publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1980.tb04528.x – volume: 329 start-page: 18 year: 2014 ident: 10.1016/j.molcel.2015.04.016_bib8 article-title: Poly(ADP-ribose) polymerases in double-strand break repair: focus on PARP1, PARP2 and PARP3 publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2014.07.003 – volume: 59 start-page: 1534 year: 2002 ident: 10.1016/j.molcel.2015.04.016_bib26 article-title: The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-002-8527-2 – volume: 20 start-page: 512 year: 2010 ident: 10.1016/j.molcel.2015.04.016_bib31 article-title: The roles of PARP1 in gene control and cell differentiation publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2010.06.001 – volume: 161 start-page: 1215 year: 2015 ident: 10.1016/j.molcel.2015.04.016_bib81 article-title: Integrative clinical genomics of advanced prostate cancer publication-title: Cell doi: 10.1016/j.cell.2015.05.001 – volume: 34 start-page: 6170 year: 2006 ident: 10.1016/j.molcel.2015.04.016_bib78 article-title: PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl840 – volume: 376 start-page: 235 year: 2010 ident: 10.1016/j.molcel.2015.04.016_bib75 article-title: Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial publication-title: Lancet doi: 10.1016/S0140-6736(10)60892-6 – volume: 19 start-page: 664 year: 2011 ident: 10.1016/j.molcel.2015.04.016_bib9 article-title: Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.04.010 – volume: 451 start-page: 81 year: 2008 ident: 10.1016/j.molcel.2015.04.016_bib1 article-title: Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins publication-title: Nature doi: 10.1038/nature06420 – volume: 15 start-page: 852 year: 2014 ident: 10.1016/j.molcel.2015.04.016_bib39 article-title: Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(14)70228-1 – volume: 26 start-page: 75 year: 2015 ident: 10.1016/j.molcel.2015.04.016_bib5 article-title: Poly(ADP-ribose) polymerases as modulators of mitochondrial activity publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2014.11.003 – volume: 38 start-page: 325 year: 1982 ident: 10.1016/j.molcel.2015.04.016_bib14 article-title: Potentiation of cell killing by inhibitors of poly(ADP-ribose) polymerase in four rodent cell lines exposed to N-methyl-N-nitrosourea or UV light publication-title: Chem. Biol. Interact. doi: 10.1016/0009-2797(82)90062-X – volume: 110 start-page: 1658 year: 2013 ident: 10.1016/j.molcel.2015.04.016_bib61 article-title: Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1209507110 – volume: 92 start-page: 310 year: 2009 ident: 10.1016/j.molcel.2015.04.016_bib29 article-title: Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence publication-title: Radiother. Oncol. doi: 10.1016/j.radonc.2009.06.024 – volume: 41 start-page: 33 year: 2011 ident: 10.1016/j.molcel.2015.04.016_bib62 article-title: PARP-3 and APLF function together to accelerate nonhomologous end-joining publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.12.006 – volume: 460 start-page: 1 year: 2000 ident: 10.1016/j.molcel.2015.04.016_bib67 article-title: Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? publication-title: Mutat. Res. doi: 10.1016/S0921-8777(00)00016-1 – volume: 366 start-page: 1382 year: 2012 ident: 10.1016/j.molcel.2015.04.016_bib38 article-title: Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1105535 – volume: 12 start-page: 1069 year: 2014 ident: 10.1016/j.molcel.2015.04.016_bib65 article-title: Transcriptional roles of PARP1 in cancer publication-title: Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-13-0672 – volume: 3 start-page: 1245 year: 2013 ident: 10.1016/j.molcel.2015.04.016_bib58 article-title: Androgen receptor signaling regulates DNA repair in prostate cancers publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-13-0172 – volume: 346 start-page: 641 year: 2000 ident: 10.1016/j.molcel.2015.04.016_bib34 article-title: Evidence for regulation of NF-kappaB by poly(ADP-ribose) polymerase publication-title: Biochem. J. doi: 10.1042/bj3460641 – volume: 1410 start-page: 122 year: 2011 ident: 10.1016/j.molcel.2015.04.016_bib48 article-title: MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model publication-title: Brain Res. doi: 10.1016/j.brainres.2011.05.069 – volume: 6 start-page: e252 year: 2008 ident: 10.1016/j.molcel.2015.04.016_bib63 article-title: The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0060252 – volume: 3 start-page: 1254 year: 2013 ident: 10.1016/j.molcel.2015.04.016_bib22 article-title: A hormone-DNA repair circuit governs the response to genotoxic insult publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-13-0108 – volume: 32 start-page: 3840 year: 2014 ident: 10.1016/j.molcel.2015.04.016_bib53 article-title: Phase III study of iniparib plus gemcitabine and carboplatin versus gemcitabine and carboplatin in patients with metastatic triple-negative breast cancer publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2014.55.2984 – volume: 99 start-page: 3270 year: 2002 ident: 10.1016/j.molcel.2015.04.016_bib24 article-title: Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.052712399 – volume: 1846 start-page: 201 year: 2014 ident: 10.1016/j.molcel.2015.04.016_bib44 article-title: Inhibition of poly(ADP-ribosyl)ation in cancer: old and new paradigms revisited publication-title: Biochim. Biophys. Acta – volume: 7 start-page: 108 year: 2001 ident: 10.1016/j.molcel.2015.04.016_bib76 article-title: Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation publication-title: Nat. Med. doi: 10.1038/83241 – volume: 276 start-page: 47664 year: 2001 ident: 10.1016/j.molcel.2015.04.016_bib12 article-title: The sequence-specific DNA binding of NF-kappa B is reversibly regulated by the automodification reaction of poly (ADP-ribose) polymerase 1 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M104666200 – volume: 20 start-page: 508 year: 2013 ident: 10.1016/j.molcel.2015.04.016_bib30 article-title: A family of macrodomain proteins reverses cellular mono-ADP-ribosylation publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.2523 – volume: 16 start-page: 87 year: 2015 ident: 10.1016/j.molcel.2015.04.016_bib55 article-title: Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(14)71135-0 – volume: 45 start-page: 64 year: 2012 ident: 10.1016/j.molcel.2015.04.016_bib57 article-title: Activator-induced spread of poly(ADP-ribose) polymerase promotes nucleosome loss at Hsp70 publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.11.015 – reference: 18922045 - PLoS Biol. 2008 Oct 14;6(10):e252 – reference: 21892188 - Nature. 2011 Sep 29;477(7366):616-20 – reference: 24027197 - Cancer Discov. 2013 Nov;3(11):1254-71 – reference: 22178397 - Mol Cell. 2012 Jan 13;45(1):64-74 – reference: 11577079 - J Biol Chem. 2001 Dec 14;276(50):47664-70 – reference: 23103912 - Nat Cell Biol. 2012 Nov;14(11):1223-30 – reference: 24508391 - Mol Cell. 2014 Mar 6;53(5):831-42 – reference: 15829967 - Nature. 2005 Apr 14;434(7035):917-21 – reference: 19364882 - J Exp Med. 2009 May 11;206(5):1047-56 – reference: 25349301 - J Clin Oncol. 2014 Dec 1;32(34):3840-7 – reference: 11877304 - Blood. 2002 Mar 15;99(6):2241-4 – reference: 16516457 - Curr Opin Cell Biol. 2006 Apr;18(2):145-51 – reference: 18258916 - Science. 2008 Feb 8;319(5864):819-21 – reference: 10494847 - Biol Chem. 1999 Jul-Aug;380(7-8):953-9 – reference: 25026313 - Biochim Biophys Acta. 2014 Aug;1846(1):201-15 – reference: 20609468 - Lancet. 2010 Jul 24;376(9737):245-51 – reference: 19680243 - Nat Struct Mol Biol. 2009 Sep;16(9):923-9 – reference: 24882434 - Lancet Oncol. 2014 Jul;15(8):852-61 – reference: 16912188 - Cancer Res. 2006 Aug 15;66(16):8109-15 – reference: 20832725 - Mol Cell. 2010 Sep 10;39(5):736-49 – reference: 24392349 - Front Oncol. 2013 Dec 20;3:301 – reference: 22452356 - N Engl J Med. 2012 Apr 12;366(15):1382-92 – reference: 15607978 - Cell. 2004 Dec 17;119(6):815-29 – reference: 25497347 - Trends Endocrinol Metab. 2015 Feb;26(2):75-83 – reference: 19666485 - Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13770-4 – reference: 12440774 - Cell Mol Life Sci. 2002 Sep;59(9):1534-53 – reference: 8700830 - Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1753-8 – reference: 17088286 - Nucleic Acids Res. 2006;34(21):6170-82 – reference: 14019961 - Biochem Biophys Res Commun. 1963 Apr 2;11:39-43 – reference: 23474712 - Nat Struct Mol Biol. 2013 Apr;20(4):508-14 – reference: 25553460 - Front Biosci (Landmark Ed). 2015;20:440-57 – reference: 10537360 - Clin Cancer Res. 1999 Oct;5(10):2908-17 – reference: 23955771 - Nat Methods. 2013 Oct;10(10):981-4 – reference: 21211721 - Mol Cell. 2011 Jan 7;41(1):33-45 – reference: 11854472 - Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3270-5 – reference: 24473064 - Cancer Res. 2014 Mar 15;74(6):1651-60 – reference: 10331651 - Mol Cell Biochem. 1999 Mar;193(1-2):149-52 – reference: 21575865 - Cancer Cell. 2011 May 17;19(5):664-78 – reference: 22291137 - Clin Cancer Res. 2012 Mar 15;18(6):1655-62 – reference: 6245884 - Eur J Biochem. 1980 Apr;105(3):525-30 – reference: 18535785 - J Thromb Thrombolysis. 2009 May;27(4):359-64 – reference: 23319653 - Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1658-63 – reference: 2770765 - Mutat Res. 1989 Sep;218(2):67-74 – reference: 21741620 - Brain Res. 2011 Sep 2;1410:122-31 – reference: 25220415 - Oncogene. 2015 Jun;34(26):3349-56 – reference: 21945626 - DNA Repair (Amst). 2011 Nov 10;10(11):1145-53 – reference: 16123586 - Cell Cycle. 2005 Sep;4(9):1176-8 – reference: 25286972 - Nat Rev Clin Oncol. 2015 Jan;12(1):27-41 – reference: 10449410 - EMBO J. 1999 Aug 16;18(16):4446-54 – reference: 22713970 - Nat Rev Mol Cell Biol. 2012 Jul;13(7):411-24 – reference: 23357755 - Mol Aspects Med. 2013 Dec;34(6):1109-23 – reference: 19812418 - J Biol Chem. 2009 Dec 4;284(49):33926-38 – reference: 24137565 - Front Oncol. 2013 Sep 30;3:257 – reference: 19553641 - N Engl J Med. 2009 Jul 9;361(2):123-34 – reference: 22993403 - Cancer Discov. 2012 Dec;2(12):1134-49 – reference: 22391446 - Genes Dev. 2012 Mar 1;26(5):417-32 – reference: 16740713 - Cancer Res. 2006 Jun 1;66(11):5744-56 – reference: 18172500 - Nature. 2008 Jan 3;451(7174):81-5 – reference: 25017100 - Exp Cell Res. 2014 Nov 15;329(1):18-25 – reference: 19926276 - Eur J Cancer. 2010 Jan;46(1):9-20 – reference: 23022557 - FEBS Lett. 2012 Nov 2;586(21):3771-7 – reference: 23711178 - FEBS J. 2013 Aug;280(15):3491-507 – reference: 26282658 - J Clin Oncol. 2015 Nov 20;33(33):3858-65 – reference: 19629035 - EMBO J. 2009 Sep 2;28(17):2601-15 – reference: 24027196 - Cancer Discov. 2013 Nov;3(11):1245-53 – reference: 25481791 - Lancet Oncol. 2015 Jan;16(1):87-97 – reference: 11135624 - Nat Med. 2001 Jan;7(1):108-13 – reference: 23118055 - Cancer Res. 2012 Nov 1;72(21):5588-99 – reference: 22447567 - Cancer Res. 2012 Jun 1;72(11):2814-21 – reference: 24916104 - Mol Cancer Res. 2014 Aug;12(8):1069-80 – reference: 20609467 - Lancet. 2010 Jul 24;376(9737):235-44 – reference: 25168287 - Cancer Discov. 2014 Oct;4(10):1126-39 – reference: 20591646 - Curr Opin Genet Dev. 2010 Oct;20(5):512-8 – reference: 10698690 - Biochem J. 2000 Mar 15;346 Pt 3:641-9 – reference: 19604590 - Radiother Oncol. 2009 Sep;92(3):310-5 – reference: 7698643 - Genes Dev. 1995 Mar 1;9(5):509-20 – reference: 23370117 - Mol Aspects Med. 2013 Dec;34(6):1217-56 – reference: 6277522 - Chem Biol Interact. 1982 Feb;38(3):325-38 – reference: 10856830 - Mutat Res. 2000 Jun 30;460(1):1-15 |
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| Snippet | Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related... Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related... Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have clinical impact in a number of disease settings, particularly as related to cancer... |
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| SubjectTerms | chromatin Chromatin - genetics disease control DNA Repair Enzyme Inhibitors - therapeutic use Humans inflammation Molecular Targeted Therapy - methods Molecular Targeted Therapy - trends NAD ADP-ribosyltransferase neoplasms Neoplasms - drug therapy Neoplasms - genetics Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism therapeutics transcription (genetics) Transcription, Genetic Translational Medical Research - methods Translational Medical Research - trends |
| Title | Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function |
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