Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 33; no. 8; pp. 1425 - 1430
• Main Authors: Fortunato, Jucélia J., Réus, Gislaine Z., Kirsch, Tamires R., Stringari, Roberto B., Stertz, Laura, Kapczinski, Flávio, Pinto, Joel P., Hallak, Jaime E., Zuardi, Antônio W., Crippa, José A., Quevedo, João
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 13.11.2009; Elsevier
• Subjects: Adult and adolescent clinical studies; Analysis of Variance; Animals; Antidepressive Agents - pharmacology; BDNF; Biological and medical sciences; Brain-Derived Neurotrophic Factor - metabolism; Depression; Depression - drug therapy; Depression - pathology; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay - methods; Forced swimming test; Harmine; Harmine - pharmacology; Hippocampus - drug effects; Hippocampus - metabolism; Imipramine; Imipramine - pharmacology; Male; Medical sciences; Mood disorders; Neuropharmacology; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Rats; Rats, Wistar; Swimming - psychology; Forced swimming test; Imipramine; MAO-A; BDNF; Depression; CDK; MDD; Harmine; 5-HT2A; Rat; Psychotropic; Central nervous system; Reuptake inhibitor; Encephalon; Antidepressant agent; Brain derived neurotrophic factor; Mood disorder; Serotonin; Acute; Rodentia; Catecholamine; Tricyclic compound; Stress; Vertebrata; Mammalia; Animal; Neurotransmitter; Norepinephrine; Hippocampus

Harmine is a β-carboline alkaloid that inhibits monoamine reuptake systems. Findings point to an antidepressant effect of the compounds that increases the levels of monoamines after monoamine oxidase inhibition. The present study aims to compare the behavioral effects and the BDNF hippocampus levels...