Implementation of accelerated research: strategies for implementation as applied in a phase 1 Ad26.ZEBOV, MVA-BN-Filo two-dose Ebola vaccine clinical trial in Uganda

• Published in: Global health action Vol. 13; no. 1; p. 1829829
• Main Authors: Kitonsa, Jonathan, Ggayi, Abu-Baker, Anywaine, Zacchaeus, Kisaakye, Eva, Nsangi, Laura, Basajja, Vincent, Nyantaro, Mary, Watson-Jones, Deborah, Shukarev, Georgi, Ilsbroux, Ine, Robinson, Cynthia, Kaleebu, Pontiano
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31.12.2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: accelerated conduct; Adolescent; Adult; Africa, Western; Clinical research; Clinical trials; Ebola Vaccines - administration & dosage; Ebola Vaccines - immunology; Ebola virus; Ebola virus disease; Ebolavirus; Epidemics; Ethics; expedited approval; Female; Health education; Hemorrhagic Fever, Ebola - epidemiology; Hemorrhagic Fever, Ebola - prevention & control; Humans; Hygiene; Immunization; Implementation; Male; Medical research; Middle Aged; Original; Public health; Recruitment; Regulatory agencies; Research Design; Single-Blind Method; Tropical medicine; Uganda; vaccine research; Vaccines; Young Adult; Uganda; Africa, Western; expedited approval; vaccine research; accelerated conduct; Ebola virus disease

The 2013-2016 Ebola epidemic in West Africa is the worst ever caused by Ebolaviruses with over 28,000 human cases and 11,325 deaths. The World Health Organisation (WHO) declared the epidemic a public health crisis that required accelerated development of novel interventions including vaccines. The M...