Long-term clinical and safety outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic thoracic spinal cord injury

• Published in: Cell reports. Medicine Vol. 5; no. 12; p. 101841
• Main Authors: Martin, Joel R., Cleary, Daniel, Abraham, Mickey E., Mendoza, Michelle, Cabrera, Betty, Jamieson, Catriona, Marsala, Martin, Ciacci, Joseph D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.12.2024; Elsevier
• Subjects: Adult; Advanced Basic Science; Chronic Disease; clinical trial; Female; Humans; Male; Middle Aged; neural stem cell therapy; Neural Stem Cells - transplantation; neurosurgery; regenerative medicine; SCI; Spinal Cord Injuries - therapy; spinal cord injury; spinal surgery; Stem Cell Transplantation - adverse effects; Stem Cell Transplantation - methods; stem cells; Treatment Outcome; spinal cord injury; clinical trial; stem cells; regenerative medicine; SCI; spinal surgery; neural stem cell therapy; neurosurgery

We report the long-term results for a phase 1 study of neural stem cell transplantation for chronic spinal cord injury. The trial was registered on ClinicalTrials.gov as NCT01772810. The primary outcome of the trial was to test the feasibility and safety of human spinal cord-derived neural stem cell...