Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function

• Published in: European journal of pharmacology Vol. 778; pp. 56 - 67
• Main Authors: Kulinski, Joseph M., Muñoz-Cano, Rosa, Olivera, Ana
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.05.2016
• Subjects: Allergy; Animals; Eicosanoids; Eicosanoids - metabolism; Humans; Hypersensitivity - immunology; Lipid mediators; Lysophospholipids - biosynthesis; Lysophospholipids - metabolism; Mast cells; Mast Cells - cytology; Mast Cells - metabolism; Mast Cells - pathology; Platelet activating factor; Platelet Activating Factor - metabolism; Sphingosine - analogs & derivatives; Sphingosine - biosynthesis; Sphingosine - metabolism; Sphingosine-1-phosphate; PGD2; NO; Allergy; eNOS; 5-LO; SphK; Eicosanoids; Prostaglandin E2 (CID: 5280360); Cys-LT; LTC4S; TNF; RBL-2H3; Prostaglandin D2 (CID: 448457); S1P; PI3K; Platelet activating factor (CID: 108156); Sphingosine-1-phosphate; LTB4; S1P1–5; FTY720 (CID: 107969); AA; PGE2; ABCC1; PGDS; PLA2; DP1-2; TRAF2; COX; Platelet activating factor; PAF; KIT; SCF; BLT1-2; GPCR; FcεRI; LTC4; Sphingosine-1-phosphate (CID: 5283560); Mast cells; CysLT1–2; Leukotriene C4 (CID: 5280493); Lipid mediators; BMMC

Sphingosine-1-phosphate (S1P), platelet activating factor (PAF) and eicosanoids are bioactive lipid mediators abundantly produced by antigen-stimulated mast cells that exert their function mostly through specific cell surface receptors. Although it has long been recognized that some of these bioacti...