Genetic diversity and host adaptation of avian H5N1 influenza viruses during human infection

• Published in: Emerging microbes & infections Vol. 8; no. 1; pp. 262 - 271
• Main Authors: Welkers, Matthijs R.A., Pawestri, Hana A., Fonville, Judy M., Sampurno, Ondri D., Pater, Maarten, Holwerda, Melle, Han, Alvin X., Russell, Colin A., Jeeninga, Rienk E., Setiawaty, Vivi, de Jong, Menno D., Eggink, Dirk
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2019; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Adaptation; Amino Acid Substitution; Amino acids; Avian flu; Evolution, Molecular; Genomes; H5N1; HEK293 Cells; High-Throughput Nucleotide Sequencing - methods; human adaptation; Humans; Indonesia; Infections; Influenza; Influenza A Virus, H5N1 Subtype - classification; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - isolation & purification; Influenza, Human - virology; polymerase complex; Protein Conformation; Viral Proteins - chemistry; Viral Proteins - genetics; Whole Genome Sequencing - methods; Indonesia; H5N1; polymerase complex; human adaptation; Influenza

The continuing pandemic threat posed by avian influenza A/H5N1 viruses calls for improved insights into their evolution during human infection. We performed whole genome deep sequencing of respiratory specimens from 44 H5N1-infected individuals from Indonesia and found substantial within-host viral...