Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice

• Published in: Drug delivery Vol. 29; no. 1; pp. 925 - 936
• Main Authors: Mao, Ruifeng, Yang, Menglan, Yang, Rui, Chen, Yingying, Diao, Enjie, Zhang, Tong, Li, Dengchao, Chang, Xin, Chi, Zhenjing, Wang, Yefu
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Animals; antigen delivery; Antigens; bacterium-like particles; Diabetes; Diabetes Mellitus, Type 1 - prevention & control; Immunization; Insulin; insulinoma-associated protein 2; Mice; Mice, Inbred NOD; Neuroendocrine tumors; oral tolerance; Proteins; Receptor-Like Protein Tyrosine Phosphatases, Class 8; T-Lymphocytes, Regulatory; Type 1 diabetes mellitus; antigen delivery; insulinoma-associated protein 2; oral tolerance; bacterium-like particles; Type 1 diabetes mellitus

Antigen-specific immune tolerance, which possesses great potential in preventing or curing type 1 diabetes mellitus (T1DM), can be induced by oral vaccination with T1DM-related autoantigens. However, direct administration of autoantigens via oral route exhibits a low tolerance-inducing effect as a r...