Skeletal Muscle Transcriptomic Comparison between Long-Term Trained and Untrained Men and Women

• Published in: Cell reports (Cambridge) Vol. 31; no. 12; p. 107808
• Main Authors: Chapman, Mark A., Arif, Muhammad, Emanuelsson, Eric B., Reitzner, Stefan M., Lindholm, Maléne E., Mardinoglu, Adil, Sundberg, Carl Johan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.06.2020
• Subjects: Adult; Aerobiosis; Athletes; Biopsy; endurance training; exercise physiology; Female; gene expression; Gene Ontology; Genome, Human; genome-scale metabolic model; human subjects; Humans; Male; Medicin och hälsovetenskap; Middle Aged; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Physical Endurance; Resistance Training; Rest; RNA sequencing; Sedentary Behavior; Sequence Analysis, RNA; Sex Characteristics; skeletal muscle; skeletal muscle metabolism; skeletal muscle transcriptomics; Transcriptome - genetics; RNA sequencing; resistance training; skeletal muscle transcriptomics; exercise physiology; skeletal muscle metabolism; endurance training; human subjects; skeletal muscle; gene expression; genome-scale metabolic model

To better understand the health benefits of lifelong exercise in humans, we conduct global skeletal muscle transcriptomic analyses of long-term endurance- (9 men, 9 women) and strength-trained (7 men) humans compared with age-matched untrained controls (7 men, 8 women). Transcriptomic analysis, Gene...