Monocyte transcriptomic profile following EPA and DHA supplementation in men and women with low-grade chronic inflammation

• Published in: Atherosclerosis Vol. 388; p. 117407
• Main Authors: So, Jisun, Wu, Dayong, Tai, Albert K., Lichtenstein, Alice H., Matthan, Nirupa R., Lamon-Fava, Stefania
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.01.2024
• Subjects: Dietary Supplements; Docosahexaenoic Acids; Double-Blind Method; Eicosapentaenoic Acid - therapeutic use; Fatty Acids, Omega-3; Female; Gene Expression Profiling; Humans; Inflammation; Macrophages; Male; Monocytes; Omega-3 fatty acids; Specialized pro-resolving lipid mediators; Transcriptome; Transcriptomics; Monocytes; Macrophages; Transcriptomics; Specialized pro-resolving lipid mediators; Omega-3 fatty acids

Recent data indicate considerable variability in response to very long chain omega-3 fatty acid supplementation on cardiovascular disease risk. This inconsistency may be due to differential effects of EPA vs DHA and/or sex-specific responses. Sixteen subjects (eight men and eight women) 50–75 y and...