Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand

• Published in: NeuroImage (Orlando, Fla.) Vol. 48; no. 2; pp. 362 - 370
• Main Authors: Terry, Garth E., Liow, Jeih-San, Zoghbi, Sami S., Hirvonen, Jussi, Farris, Amanda G., Lerner, Alicja, Tauscher, Johannes T., Schaus, John M., Phebus, Lee, Felder, Christian C., Morse, Cheryl L., Hong, Jinsoo S., Pike, Victor W., Halldin, Christer, Innis, Robert B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2009; Elsevier Limited
• Subjects: Adult; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain imaging; Computer Simulation; Female; Human subjects; Humans; Kinetics; Magnetic Resonance Imaging; Male; Models, Neurological; Neuroimaging; Plasma; Positron emission tomography; Pyrrolidinones - blood; Pyrrolidinones - pharmacokinetics; Receptor, Cannabinoid, CB1 - agonists; Receptor, Cannabinoid, CB1 - metabolism; Reproducibility of Results; Studies; Neuroimaging; Positron emission tomography; Brain imaging

[11C]MePPEP is a high affinity, CB1 receptor-selective, inverse agonist that has been studied in rodents and monkeys. We examined the ability of [11C]MePPEP to quantify CB1 receptors in human brain as distribution volume calculated with the “gold standard” method of compartmental modeling and compar...