Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function

• Published in: Molecular cell Vol. 69; no. 2; pp. 279 - 291.e5
• Main Authors: Wan, Lixin, Xu, Kexin, Wei, Yongkun, Zhang, Jinfang, Han, Tao, Fry, Christopher, Zhang, Zhao, Wang, Yao Vickie, Huang, Liyu, Yuan, Min, Xia, Weiya, Chang, Wei-Chao, Huang, Wen-Chien, Liu, Chien-Liang, Chang, Yuan-Ching, Liu, Jinsong, Wu, Yun, Jin, Victor X., Dai, Xiangpeng, Guo, Jianfeng, Liu, Jia, Jiang, Shulong, Li, Jin, Asara, John M., Brown, Myles, Hung, Mien-Chie, Wei, Wenyi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.01.2018
• Subjects: agonists; AMP-activated protein kinase; AMP-Activated Protein Kinases - metabolism; AMPK; animal ovaries; Animals; autophagy; breast neoplasms; Carcinogenesis - genetics; cell culture; Cell Cycle; cell growth; Cell Line, Tumor; Cell Proliferation; DNA Methylation; DNA-Binding Proteins - metabolism; energy; Enhancer of Zeste Homolog 2 Protein - genetics; Enhancer of Zeste Homolog 2 Protein - metabolism; Enhancer of Zeste Homolog 2 Protein - physiology; enzyme activity; Epigenesis, Genetic; EZH2; Female; gene expression regulation; genes; histones; Histones - metabolism; Humans; immunohistochemistry; metformin; methylation; methyltransferases; Mice; neoplasm cells; Neoplasm Proteins; Nuclear Proteins - metabolism; Oncogenes; ovarian cancer; Ovarian Neoplasms - metabolism; patients; Phosphorylation; polycomb repressive complex 2; Polycomb Repressive Complex 2 - metabolism; Polycomb Repressive Complex 2 - physiology; protein synthesis; starvation; Transcription Factors; Up-Regulation; xenotransplantation; AMPK; polycomb repressive complex 2; metformin; ovarian cancer; phosphorylation; EZH2

Sustained energy starvation leads to activation of AMP-activated protein kinase (AMPK), which coordinates energy status with numerous cellular processes including metabolism, protein synthesis, and autophagy. Here, we report that AMPK phosphorylates the histone methyltransferase EZH2 at T311 to disr...