Alpha‐actinin‐4 is essential for maintaining normal trophoblast proliferation and differentiation during early pregnancy

• Published in: Reproductive biology and endocrinology Vol. 19; no. 1; pp. 48 - 12
• Main Authors: Peng, Wei, Liu, Ying, Qi, Hongbo, Li, Qingshu
• Format: Journal Article
• Language: English
• Published: England BioMed Central 23.03.2021; BMC
• Subjects: Achievement tests; Actin; Actinin; ACTN4; AKT protein; Cell adhesion & migration; Cell culture; Cell migration; Cytoskeleton; Explants; Filaments; Gene expression; Gestation; Hypertension; Immunofluorescence; Immunohistochemistry; Invasion and migration; Membranes; Mesenchyme; Monoclonal antibodies; Motility; Placenta; Pre-eclampsia; Preeclampsia; Pregnancy; Proliferation; Proteins; siRNA; Transfection; Trophoblast; Trophoblasts; Wound healing; Beijing China; California; United States > US; China; Trophoblast; ACTN4; Proliferation; Invasion and migration; Preeclampsia

Proper differentiation of trophoblasts in the human placenta is essential for a successful pregnancy, whereas abnormal regulation of this process may lead to adverse pregnancy outcomes, especially preeclampsia (PE). However, the underlying mechanism of trophoblast differentiation remains unclear. Pr...