Meta-analysis of diagnostic performance of serology tests for COVID-19: impact of assay design and post-symptom-onset intervals

• Published in: Emerging microbes & infections Vol. 9; no. 1; pp. 2200 - 2211
• Main Authors: Wang, Hongyu, Ai, Jingwen, Loeffelholz, Michael J., Tang, Yi-Wei, Zhang, Wenhong
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Accuracy; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antigens, Viral - immunology; Betacoronavirus - immunology; Clinical Laboratory Techniques - methods; Clinical Laboratory Techniques - standards; Coronavirus Infections - diagnosis; Coronavirus Infections - immunology; Coronavirus Infections - virology; Coronaviruses; COVID-19; COVID-19 Testing; Humans; Immunoassay; Immunoassay - methods; Immunoassay - standards; immunoassays; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunoglobulin M - blood; Immunoglobulin M - immunology; Meta-analysis; metanalysis; Pandemics; Pneumonia, Viral - diagnosis; Pneumonia, Viral - immunology; Pneumonia, Viral - virology; Publication Bias; SARS-CoV-2; Sensitivity and Specificity; Serologic Tests - methods; Serologic Tests - standards; Serology; Symptom Assessment; COVID-19; immunoassays; SARS-CoV-2; metanalysis; serology

Serology detection is recognized for its sensitivity in convalescent patients with COVID-19, in comparison with nucleic acid amplification tests (NAATs). This article aimed to evaluate the diagnostic accuracy of serologic methods for COVID-19 based on assay design and post-symptom-onset intervals. T...