Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy

• Published in: Drug delivery Vol. 29; no. 1; pp. 138 - 148
• Main Authors: Liu, Xue, Wu, Zhenfeng, Guo, Chunjing, Guo, Huimin, Su, Yanguo, Chen, Qiang, Sun, Changgang, Liu, Qingming, Chen, Daquan, Mu, Hongjie
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Angelica; angelica polysaccharide; Arachidonic Acid - chemistry; Azo Compounds - chemistry; Cell Survival - drug effects; Chemistry, Pharmaceutical; Drug Carriers - chemistry; Drug delivery systems; Drug Liberation; Ferroptosis; Ferrous Compounds - chemistry; Hep G2 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Hypoxia; Hypoxia - metabolism; Hypoxia responsive; Liver cancer; Liver Neoplasms - pathology; Metallocenes - chemistry; micelle; Micelles; Nanoparticle Drug Delivery System - chemistry; Particle Size; Polymers; Polysaccharides - administration & dosage; Polysaccharides - pharmacology; Surface Properties; micelle; angelica polysaccharide; liver cancer; ferroptosis; Hypoxia responsive

Based on the tumor hypoxic microenvironment and the new programmed cell death mode of combined ferroptosis, an angelica polysaccharide-based nanocarrier material was synthesized. The polymer contains hydrophilic angelica polysaccharide (ASP) that is linked by azobenzene (AZO) linker with ferrocene (...