Pulmonary exposure to cellulose nanocrystals caused deleterious effects to reproductive system in male mice

• Published in: Journal of Toxicology and Environmental Health, Part A Vol. 79; no. 21; pp. 984 - 997
• Main Authors: Farcas, Mariana T., Kisin, Elena R., Menas, Autumn L., Gutkin, Dmitriy W., Star, Alexander, Reiner, Richard S., Yanamala, Naveena, Savolainen, Kai, Shvedova, Anna A.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2016; Taylor & Francis Ltd
• Subjects: Animals; Cellulose; Cellulose - toxicity; Computer numerical control; DNA Damage; Epididymis - drug effects; Exposure; Inhalation Exposure - analysis; Luteinizing Hormone - blood; Male; Males; Mice; Mice, Inbred C57BL; Motility; Nanocrystals; Nanoparticles - toxicity; Reproductive system; Reproductive systems; Rodents; Sperm; Sperm Count; Spermatozoa - drug effects; Testes; Testosterone; Testosterone - blood; Testosterone - metabolism; Toxicity

Over the past several years there has been an increased number of applications of cellulosic materials in many sectors, including the food industry, cosmetics, and pharmaceuticals. However, to date, there are few studies investigating the potential adverse effects of cellulose nanocrystals (CNC). Th...