Stressed to death: Mitochondrial stress responses connect respiration and apoptosis in cancer

• Published in: Molecular cell Vol. 82; no. 18; pp. 3321 - 3332
• Main Authors: Winter, Jacob M., Yadav, Tarun, Rutter, Jared
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.09.2022
• Subjects: Apoptosis; cancer; cancer therapy; CRISPR; death; electron transport chain; Humans; integrated stress response; leukemia; mitochondria; Mitochondria - metabolism; Neoplasms - genetics; Neoplasms - metabolism; oncology; oxidative phosphorylation; Oxidative Stress; Respiration; Signal Transduction; stress; stress response; venetoclax; stress; leukemia; CRISPR; electron transport chain; mitochondria; apoptosis; cancer; respiration; venetoclax; oxidative phosphorylation; oncology; integrated stress response

Mitochondrial energetics and respiration have emerged as important factors in how cancer cells respond to or evade apoptotic signals. The study of the functional connection between these two processes may provide insight into following questions old and new: how might we target respiration or downst...