Broadly neutralizing antibodies for HIV-1: efficacies, challenges and opportunities

• Published in: Emerging microbes & infections Vol. 9; no. 1; pp. 194 - 206
• Main Authors: Liu, Yubin, Cao, Wei, Sun, Ming, Li, Taisheng
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Animals; Antiretroviral drugs; broadly neutralizing antibodies (bNAbs); Broadly Neutralizing Antibodies - immunology; challenges; Clinical Trials as Topic; Drug Resistance, Viral; efficacies; HIV; HIV Infections - immunology; HIV-1; HIV-1 - immunology; Human immunodeficiency virus; Humans; Immunotherapy; opportunities; Review; HIV-1; broadly neutralizing antibodies (bNAbs); challenges; opportunities; efficacies

Combination antiretroviral therapy (cART) is effective but not curative, and no successful vaccine is currently available for human immunodeficiency virus-1 (HIV-1). Broadly neutralizing antibodies (bNAbs) provide a new approach to HIV-1 prevention and treatment, and these promising candidates advan...