Stress Induces p38 MAPK-Mediated Phosphorylation and Inhibition of Drosha-Dependent Cell Survival

• Published in: Molecular cell Vol. 57; no. 4; pp. 721 - 734
• Main Authors: Yang, Qian, Li, Wenming, She, Hua, Dou, Juan, Duong, Duc M., Du, Yuhong, Yang, Shao-Hua, Seyfried, Nicholas T., Fu, Haian, Gao, Guodong, Mao, Zixu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.02.2015
• Subjects: Active Transport, Cell Nucleus; biogenesis; calpain; Cell Survival; cell viability; death; genes; HEK293 Cells; Humans; messenger RNA; microRNA; mitogen-activated protein kinase; p38 Mitogen-Activated Protein Kinases - genetics; p38 Mitogen-Activated Protein Kinases - metabolism; p38 Mitogen-Activated Protein Kinases - physiology; Phosphorylation; physiological transport; Proteolysis; Ribonuclease III - genetics; Ribonuclease III - metabolism; Ribonuclease III - physiology; ribonucleases; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; RNA-Binding Proteins - physiology; Stress, Physiological; translation (genetics)

MicroRNAs (miRNAs) regulate the translational potential of their mRNA targets and control many cellular processes. The key step in canonical miRNA biogenesis is the cleavage of the primary transcripts by the nuclear RNase III enzyme Drosha. Emerging evidence suggests that the miRNA biogenic cascade...