Control of cell proliferation by a porous chitosan scaffold with multiple releasing capabilities

• Published in: Science and technology of advanced materials Vol. 18; no. 1; pp. 987 - 996
• Main Authors: Cai, Shu-Jyun, Li, Ching-Wen, Weihs, Daphne, Wang, Gou-Jen
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2017; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: 102 Porous / Nanoporous / Nanostructured materials; 20 Organic and soft materials (colloids, liquid crystals, gel, polymers); 211 Scaffold / Tissue engineering / Drug delivery; Biocompatibility; Cell culture; Cell growth; Chitosan; controlled drug release; Controlled release; Drug delivery systems; Endothelial cells; fibroblast growth factor; Fibroblasts; Freeze drying; Freezing; Growth factors; Ice crystals; Ice formation; Organic and Soft Materials (Colloids, Liquid Crystals, Gel, Polymers); Pore size; Porosity; Porous chitosan scaffold; Scaffolds; Stability; transforming growth factor-beta 1; wound dressing; Wound healing; 20 Organic and soft materials (colloids, liquid crystals, gel, polymers); fibroblast growth factor; wound dressing; controlled drug release; transforming growth factor-beta 1; 102 Porous / Nanoporous / Nanostructured materials; 211 Scaffold / Tissue engineering / Drug delivery; Porous chitosan scaffold

The aim of this study was to develop a porous chitosan scaffold with long-acting drug release as an artificial dressing to promote skin wound healing. The dressing was fabricated by pre-freezing at different temperatures (−20 and −80 °C) for different periods of time, followed by freeze-drying to fo...