Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease
Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lip...
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| Published in | Nature communications Vol. 11; no. 1; pp. 5698 - 11 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Nature Publishing Group
10.11.2020
Nature Publishing Group UK Nature Portfolio |
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| Abstract | Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisation. In this study we examined peripheral samples of two cohorts (AIBL, n = 1112 and ADNI, n = 800). We are able to identify concordant peripheral signatures associated with prevalent AD arising from lipid pathways including; ether lipids, sphingolipids (notably GM
gangliosides) and lipid classes previously associated with cardiometabolic disease (phosphatidylethanolamine and triglycerides). We subsequently identified similar lipid signatures in both cohorts with future disease. Lastly, we developed multivariate lipid models that improved classification and prediction. Our results provide a holistic view between the lipidome and AD using a comprehensive approach, providing targets for further mechanistic investigation. |
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| AbstractList | Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisation. In this study we examined peripheral samples of two cohorts (AIBL, n = 1112 and ADNI, n = 800). We are able to identify concordant peripheral signatures associated with prevalent AD arising from lipid pathways including; ether lipids, sphingolipids (notably GM3 gangliosides) and lipid classes previously associated with cardiometabolic disease (phosphatidylethanolamine and triglycerides). We subsequently identified similar lipid signatures in both cohorts with future disease. Lastly, we developed multivariate lipid models that improved classification and prediction. Our results provide a holistic view between the lipidome and AD using a comprehensive approach, providing targets for further mechanistic investigation.The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD. Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisation. In this study we examined peripheral samples of two cohorts (AIBL, n = 1112 and ADNI, n = 800). We are able to identify concordant peripheral signatures associated with prevalent AD arising from lipid pathways including; ether lipids, sphingolipids (notably GM 3 gangliosides) and lipid classes previously associated with cardiometabolic disease (phosphatidylethanolamine and triglycerides). We subsequently identified similar lipid signatures in both cohorts with future disease. Lastly, we developed multivariate lipid models that improved classification and prediction. Our results provide a holistic view between the lipidome and AD using a comprehensive approach, providing targets for further mechanistic investigation. The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD. The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD. Abstract Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisation. In this study we examined peripheral samples of two cohorts (AIBL, n = 1112 and ADNI, n = 800). We are able to identify concordant peripheral signatures associated with prevalent AD arising from lipid pathways including; ether lipids, sphingolipids (notably GM 3 gangliosides) and lipid classes previously associated with cardiometabolic disease (phosphatidylethanolamine and triglycerides). We subsequently identified similar lipid signatures in both cohorts with future disease. Lastly, we developed multivariate lipid models that improved classification and prediction. Our results provide a holistic view between the lipidome and AD using a comprehensive approach, providing targets for further mechanistic investigation. Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisation. In this study we examined peripheral samples of two cohorts (AIBL, n = 1112 and ADNI, n = 800). We are able to identify concordant peripheral signatures associated with prevalent AD arising from lipid pathways including; ether lipids, sphingolipids (notably GM gangliosides) and lipid classes previously associated with cardiometabolic disease (phosphatidylethanolamine and triglycerides). We subsequently identified similar lipid signatures in both cohorts with future disease. Lastly, we developed multivariate lipid models that improved classification and prediction. Our results provide a holistic view between the lipidome and AD using a comprehensive approach, providing targets for further mechanistic investigation. |
| ArticleNumber | 5698 |
| Author | Smith, Adam Alexander T Lim, Wei Ling Florence Kaddurah-Daouk, Rima Martins, Ian Giles, Corey Salim, Agus Bush, Ashley I Masters, Colin L Laws, Simon M Huynh, Kevin Chatterjee, Pratishtha Meikle, Peter J Saykin, Andrew J Villemagne, Victor L Nho, Kwangsik Olshansky, Gavriel Arnold, Matthias Mellett, Natalie A Rowe, Christopher C Martins, Ralph N Drew, Brian G Ames, David Jayawardana, Kaushala S Baillie, Rebecca Han, Xianlin |
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| Cites_doi | 10.1016/j.neurobiolaging.2013.08.001 10.3233/JAD-150948 10.1038/s41588-018-0311-9 10.1194/jlr.P700023-JLR200 10.3233/JAD-2011-101608 10.1016/j.neurobiolaging.2016.03.027 10.1016/S0163-7827(01)00003-0 10.1038/nm.3466 10.3390/metabo5020389 10.1073/pnas.132384699 10.1016/j.jalz.2015.12.008 10.1016/j.neurobiolaging.2008.07.020 10.1194/jlr.R800095-JLR200 10.1152/ajpheart.00524.2001 10.1016/j.chembiol.2018.10.008 10.3233/JAD-191304 10.1194/jlr.M033506 10.3233/JAD-142319 10.1111/j.2517-6161.1995.tb02031.x 10.1038/tp.2014.127 10.1371/journal.pone.0024777 10.1016/j.jalz.2016.08.003 10.1046/j.1471-4159.2002.00997.x 10.1212/WNL.0b013e3181cb3e25 10.1093/aje/154.7.635 10.1002/iub.314 10.1016/j.ebiom.2017.02.012 10.1017/S1041610209009405 10.1194/jlr.S087163 10.1016/j.bbalip.2014.11.005 10.1186/1742-2094-9-197 10.1016/j.febslet.2004.05.037 10.1046/j.1471-4159.2001.00332.x 10.3389/fneur.2015.00237 10.2337/dc08-0272 10.1016/S0140-6736(05)67889-0 10.1111/j.1471-4159.2010.07070.x 10.1194/jlr.E400004-JLR200 10.1016/j.bbalip.2010.03.007 10.1194/jlr.M009449 10.1111/jdi.12087 10.1021/jp4029062 10.1006/bbrc.1998.9321 10.1016/j.jalz.2015.04.005 10.1371/journal.pone.0074341 |
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| References | D Li (19473_CR15) 2016; 3 PJ Meikle (19473_CR23) 2013; 8 JM Ntambi (19473_CR37) 2002; 99 19473_CR22 WLF Lim (19473_CR21) 2020; 76 O Quehenberger (19473_CR13) 2010; 51 TA Couttas (19473_CR40) 2016; 43 R Casanova (19473_CR17) 2016; 12 P Proitsi (19473_CR19) 2015; 5 G Liebisch (19473_CR49) 2013; 54 M Levy (19473_CR39) 2010; 62 T Koal (19473_CR16) 2015; 44 19473_CR2 N Nagan (19473_CR27) 2001; 40 T Fujino (19473_CR35) 2017; 17 M Mapstone (19473_CR5) 2014; 20 N Yamamoto (19473_CR8) 2004; 569 19473_CR10 DB Goodenowe (19473_CR28) 2007; 48 RC Petersen (19473_CR44) 2010; 74 E Fahy (19473_CR47) 2005; 46 MOW Grimm (19473_CR29) 2011; 116 H Cheng (19473_CR7) 2010; 31 G Astarita (19473_CR36) 2011; 6 F Dorninger (19473_CR26) 2015; 1851 E Fahy (19473_CR48) 2009; 50 IE Jansen (19473_CR12) 2019; 51 KS Vetrivel (19473_CR31) 2010; 1801 ZH Alshehry (19473_CR45) 2015; 5 K Gudala (19473_CR25) 2013; 4 P Proitsi (19473_CR18) 2017; 13 XL Han (19473_CR6) 2001; 77 L Whiley (19473_CR11) 2014; 35 LJ Pike (19473_CR30) 2001; 15 T Hoshino (19473_CR41) 2013; 117 M Igarashi (19473_CR4) 2011; 24 MS Fiandaca (19473_CR14) 2015; 6 C Raffaitin (19473_CR24) 2009; 32 DK Barupal (19473_CR20) 2019; 11 H Mandel (19473_CR32) 1998; 250 KA Ellis (19473_CR42) 2009; 21 19473_CR38 X Han (19473_CR9) 2002; 82 DB Goodenowe (19473_CR3) 2007; 48 MW Weiner (19473_CR43) 2015; 11 M Ifuku (19473_CR34) 2012; 9 Y Benjamini (19473_CR46) 1995; 57 RA Zoeller (19473_CR33) 2002; 283 CP Ferri (19473_CR1) 2005; 366 |
| References_xml | – volume: 35 start-page: 271 year: 2014 ident: 19473_CR11 publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2013.08.001 contributor: fullname: L Whiley – ident: 19473_CR10 doi: 10.3233/JAD-150948 – volume: 51 start-page: 404 year: 2019 ident: 19473_CR12 publication-title: Nat. Genet doi: 10.1038/s41588-018-0311-9 contributor: fullname: IE Jansen – volume: 48 start-page: 2485 year: 2007 ident: 19473_CR3 publication-title: J. Lipid Res. doi: 10.1194/jlr.P700023-JLR200 contributor: fullname: DB Goodenowe – volume: 24 start-page: 507 year: 2011 ident: 19473_CR4 publication-title: J. Alzheimer’s Dis. doi: 10.3233/JAD-2011-101608 contributor: fullname: M Igarashi – volume: 43 start-page: 89 year: 2016 ident: 19473_CR40 publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2016.03.027 contributor: fullname: TA Couttas – volume: 40 start-page: 199 year: 2001 ident: 19473_CR27 publication-title: Prog. Lipid Res. doi: 10.1016/S0163-7827(01)00003-0 contributor: fullname: N Nagan – volume: 20 start-page: 415 year: 2014 ident: 19473_CR5 publication-title: Nat. Med. doi: 10.1038/nm.3466 contributor: fullname: M Mapstone – volume: 5 start-page: 389 year: 2015 ident: 19473_CR45 publication-title: Metabolites doi: 10.3390/metabo5020389 contributor: fullname: ZH Alshehry – volume: 99 start-page: 11482 year: 2002 ident: 19473_CR37 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.132384699 contributor: fullname: JM Ntambi – volume: 12 start-page: 815 year: 2016 ident: 19473_CR17 publication-title: Alzheimer’s Dement. doi: 10.1016/j.jalz.2015.12.008 contributor: fullname: R Casanova – volume: 31 start-page: 1188 year: 2010 ident: 19473_CR7 publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2008.07.020 contributor: fullname: H Cheng – volume: 11 start-page: 619 year: 2019 ident: 19473_CR20 publication-title: Alzheimer’s Dement. contributor: fullname: DK Barupal – volume: 50 start-page: S9 year: 2009 ident: 19473_CR48 publication-title: J. Lipid Res. doi: 10.1194/jlr.R800095-JLR200 contributor: fullname: E Fahy – volume: 283 start-page: H671 year: 2002 ident: 19473_CR33 publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.00524.2001 contributor: fullname: RA Zoeller – ident: 19473_CR22 doi: 10.1016/j.chembiol.2018.10.008 – volume: 76 start-page: 303 year: 2020 ident: 19473_CR21 publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-191304 contributor: fullname: WLF Lim – volume: 54 start-page: 1523 year: 2013 ident: 19473_CR49 publication-title: J. Lipid Res doi: 10.1194/jlr.M033506 contributor: fullname: G Liebisch – volume: 44 start-page: 1193 year: 2015 ident: 19473_CR16 publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-142319 contributor: fullname: T Koal – volume: 57 start-page: 289 year: 1995 ident: 19473_CR46 publication-title: J. R. Stat. Soc. Ser. B (Methodol.) doi: 10.1111/j.2517-6161.1995.tb02031.x contributor: fullname: Y Benjamini – volume: 5 year: 2015 ident: 19473_CR19 publication-title: Transl. Psychiatry doi: 10.1038/tp.2014.127 contributor: fullname: P Proitsi – volume: 6 start-page: e24777 year: 2011 ident: 19473_CR36 publication-title: PLoS ONE doi: 10.1371/journal.pone.0024777 contributor: fullname: G Astarita – volume: 13 start-page: 140 year: 2017 ident: 19473_CR18 publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2016.08.003 contributor: fullname: P Proitsi – volume: 82 start-page: 809 year: 2002 ident: 19473_CR9 publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2002.00997.x contributor: fullname: X Han – volume: 74 start-page: 201 year: 2010 ident: 19473_CR44 publication-title: Neurology doi: 10.1212/WNL.0b013e3181cb3e25 contributor: fullname: RC Petersen – ident: 19473_CR38 doi: 10.1093/aje/154.7.635 – volume: 62 start-page: 347 year: 2010 ident: 19473_CR39 publication-title: IUBMB Life doi: 10.1002/iub.314 contributor: fullname: M Levy – volume: 17 start-page: 199 year: 2017 ident: 19473_CR35 publication-title: EBioMedicine doi: 10.1016/j.ebiom.2017.02.012 contributor: fullname: T Fujino – volume: 21 start-page: 672 year: 2009 ident: 19473_CR42 publication-title: Int. Psychogeriatr. doi: 10.1017/S1041610209009405 contributor: fullname: KA Ellis – volume: 3 start-page: 73 year: 2016 ident: 19473_CR15 publication-title: Alzheimers Dement. contributor: fullname: D Li – ident: 19473_CR2 doi: 10.1194/jlr.S087163 – volume: 15 start-page: A20 year: 2001 ident: 19473_CR30 publication-title: FASEB J. contributor: fullname: LJ Pike – volume: 1851 start-page: 117 year: 2015 ident: 19473_CR26 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbalip.2014.11.005 contributor: fullname: F Dorninger – volume: 9 year: 2012 ident: 19473_CR34 publication-title: J. Neuroinflammation doi: 10.1186/1742-2094-9-197 contributor: fullname: M Ifuku – volume: 569 start-page: 135 year: 2004 ident: 19473_CR8 publication-title: FEBS Lett. doi: 10.1016/j.febslet.2004.05.037 contributor: fullname: N Yamamoto – volume: 77 start-page: 1168 year: 2001 ident: 19473_CR6 publication-title: J. Neurochem doi: 10.1046/j.1471-4159.2001.00332.x contributor: fullname: XL Han – volume: 6 start-page: 237 year: 2015 ident: 19473_CR14 publication-title: Front. Neurol. doi: 10.3389/fneur.2015.00237 contributor: fullname: MS Fiandaca – volume: 32 start-page: 169 year: 2009 ident: 19473_CR24 publication-title: Diabetes Care doi: 10.2337/dc08-0272 contributor: fullname: C Raffaitin – volume: 366 start-page: 2112 year: 2005 ident: 19473_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(05)67889-0 contributor: fullname: CP Ferri – volume: 116 start-page: 916 year: 2011 ident: 19473_CR29 publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2010.07070.x contributor: fullname: MOW Grimm – volume: 46 start-page: 839 year: 2005 ident: 19473_CR47 publication-title: J. Lipid Res. doi: 10.1194/jlr.E400004-JLR200 contributor: fullname: E Fahy – volume: 1801 start-page: 860 year: 2010 ident: 19473_CR31 publication-title: Biochim Biophys. Acta doi: 10.1016/j.bbalip.2010.03.007 contributor: fullname: KS Vetrivel – volume: 51 start-page: 3299 year: 2010 ident: 19473_CR13 publication-title: J. Lipid Res. doi: 10.1194/jlr.M009449 contributor: fullname: O Quehenberger – volume: 4 start-page: 640 year: 2013 ident: 19473_CR25 publication-title: J. Diabetes Investig. doi: 10.1111/jdi.12087 contributor: fullname: K Gudala – volume: 117 start-page: 8085 year: 2013 ident: 19473_CR41 publication-title: J. Phys. Chem. B doi: 10.1021/jp4029062 contributor: fullname: T Hoshino – volume: 250 start-page: 369 year: 1998 ident: 19473_CR32 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1998.9321 contributor: fullname: H Mandel – volume: 11 start-page: 865 year: 2015 ident: 19473_CR43 publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2015.04.005 contributor: fullname: MW Weiner – volume: 8 start-page: e74341 year: 2013 ident: 19473_CR23 publication-title: PLoS ONE doi: 10.1371/journal.pone.0074341 contributor: fullname: PJ Meikle – volume: 48 start-page: 2485 year: 2007 ident: 19473_CR28 publication-title: J. Lipid Res doi: 10.1194/jlr.P700023-JLR200 contributor: fullname: DB Goodenowe |
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| Snippet | Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex molecules comprising many... Abstract Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising... Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many... The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and... |
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| SubjectTerms | Alzheimer Disease - metabolism Alzheimer's disease Biomarkers - blood Cohort Studies Computer Simulation Gangliosides Humans Lipid Metabolism Lipidomics Lipids Lipids - blood Metabolism Metabolomics Neurodegenerative diseases Pathology Phosphatidylethanolamine Signatures Sphingolipids Triglycerides |
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| Title | Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/33173055 https://www.proquest.com/docview/2471554528/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC7655942 https://doaj.org/article/4dd529924c75463b9ab9f71c074acad6 |
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