Intraepithelial lymphocytes are associated with epithelial injury in feline intestinal T-cell lymphoma

• Published in: Journal of Veterinary Medical Science Vol. 86; no. 1; pp. 101 - 110
• Main Authors: UCHIDA, Kazuyuki, GOTO-KOSHINO, Yuko, CHAMBERS, James K, II, Tatsuhito, NAKASHIMA, Ko
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2024; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Animals; Apoptosis; Caspase 3; cat; Cat Diseases; Cats; Cytotoxicity; Epithelial cells; Epithelium; feline intestinal T-cell lymphoma; Granzyme B; Granzymes - metabolism; Intestine; intraepithelial lymphocytes; Intraepithelial Lymphocytes - metabolism; Ki-67 Antigen; Lymphocytes; Lymphocytes T; Lymphoma; Lymphoma, T-Cell - veterinary; Mucosa; Pathology; T-cell lymphoma; granzyme B; apoptosis; feline intestinal T-cell lymphoma; intraepithelial lymphocytes; cat

Our previous study indicated that cytotoxicity of intraepithelial lymphocytes is a poor prognostic factor in feline intestinal T-cell lymphoma (FITL), but the effect of cytotoxic lymphocytes on mucosal epithelium is still unknown. Thus, we investigated the association between cytotoxic lymphocytes a...