Antibiofilm activity of nanosized magnesium fluoride

• Published in: Biomaterials Vol. 30; no. 30; pp. 5969 - 5978
• Main Authors: Lellouche, Jonathan, Kahana, Edith, Elias, Sivan, Gedanken, Aharon, Banin, Ehud
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2009
• Subjects: Advanced Basic Science; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - pharmacology; Antimicrobial properties; Biocompatible Materials; Biofilms; Chromosomes - metabolism; Dentistry; Drug Resistance, Bacterial; Escherichia coli - metabolism; Flow Cytometry - methods; Fluorides - chemistry; Fluorides - pharmacology; Lipid Peroxidation; Magnesium Compounds - chemistry; Magnesium Compounds - pharmacology; Magnesium fluoride; Microbial Sensitivity Tests; Microscopy, Electron, Scanning - methods; Microscopy, Electron, Transmission - methods; Nanoparticles; Nanoparticles - chemistry; Nanotechnology - methods; Staphylococcus aureus - metabolism; Sterile surfaces; Surface Properties; Nanoparticles; Sterile surfaces; Magnesium fluoride; Biofilms; Antimicrobial properties

Abstract The ability of bacteria to develop antibiotic resistance and colonize abiotic surfaces by forming biofilms is a major cause of medical implant-associated infections and results in prolonged hospitalization periods and patient mortality. This raises the urgent need to develop compounds that...