A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny
Humans and dogs are the two major hosts of Strongyloides stercoralis, an intestinal parasitic nematode. To better understand the phylogenetic relationships among S. stercoralis isolates infecting humans and dogs and to assess the zoonotic potential of this parasite, we analyzed mitochondrial Cox1, n...
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| Published in | Scientific reports Vol. 7; no. 1; pp. 4844 - 13 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Nature Publishing Group
07.07.2017
Nature Publishing Group UK Nature Portfolio |
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| Abstract | Humans and dogs are the two major hosts of Strongyloides stercoralis, an intestinal parasitic nematode. To better understand the phylogenetic relationships among S. stercoralis isolates infecting humans and dogs and to assess the zoonotic potential of this parasite, we analyzed mitochondrial Cox1, nuclear 18S rDNA, 28S rDNA, and a major sperm protein domain-containing protein genes. Overall, our analyses indicated the presence of two distinct lineages of S. stercoralis (referred to as type A and type B). While type A parasites were isolated both from humans and dogs in different countries, type B parasites were found exclusively in dogs, indicating that the type B has not adapted to infect humans. These epidemiological data, together with the close phylogenetic relationship of S. stercoralis with S. procyonis, a Strongyloides parasite of raccoons, possibly indicates that S. stercoralis originally evolved as a canid parasite, and later spread into humans. The inability to infect humans might be an ancestral character of this species and the type B might be surmised to be an origin population from which human-infecting strains are derived. |
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| AbstractList | Humans and dogs are the two major hosts of Strongyloides stercoralis, an intestinal parasitic nematode. To better understand the phylogenetic relationships among S. stercoralis isolates infecting humans and dogs and to assess the zoonotic potential of this parasite, we analyzed mitochondrial Cox1, nuclear 18S rDNA, 28S rDNA, and a major sperm protein domain-containing protein genes. Overall, our analyses indicated the presence of two distinct lineages of S. stercoralis (referred to as type A and type B). While type A parasites were isolated both from humans and dogs in different countries, type B parasites were found exclusively in dogs, indicating that the type B has not adapted to infect humans. These epidemiological data, together with the close phylogenetic relationship of S. stercoralis with S. procyonis, a Strongyloides parasite of raccoons, possibly indicates that S. stercoralis originally evolved as a canid parasite, and later spread into humans. The inability to infect humans might be an ancestral character of this species and the type B might be surmised to be an origin population from which human-infecting strains are derived. Abstract Humans and dogs are the two major hosts of Strongyloides stercoralis , an intestinal parasitic nematode. To better understand the phylogenetic relationships among S . stercoralis isolates infecting humans and dogs and to assess the zoonotic potential of this parasite, we analyzed mitochondrial Cox1, nuclear 18S rDNA, 28S rDNA, and a major sperm protein domain-containing protein genes. Overall, our analyses indicated the presence of two distinct lineages of S . stercoralis (referred to as type A and type B). While type A parasites were isolated both from humans and dogs in different countries, type B parasites were found exclusively in dogs, indicating that the type B has not adapted to infect humans. These epidemiological data, together with the close phylogenetic relationship of S . stercoralis with S . procyonis , a Strongyloides parasite of raccoons, possibly indicates that S . stercoralis originally evolved as a canid parasite, and later spread into humans. The inability to infect humans might be an ancestral character of this species and the type B might be surmised to be an origin population from which human-infecting strains are derived. Humans and dogs are the two major hosts of Strongyloides stercoralis , an intestinal parasitic nematode. To better understand the phylogenetic relationships among S . stercoralis isolates infecting humans and dogs and to assess the zoonotic potential of this parasite, we analyzed mitochondrial Cox1, nuclear 18S rDNA, 28S rDNA, and a major sperm protein domain-containing protein genes. Overall, our analyses indicated the presence of two distinct lineages of S . stercoralis (referred to as type A and type B). While type A parasites were isolated both from humans and dogs in different countries, type B parasites were found exclusively in dogs, indicating that the type B has not adapted to infect humans. These epidemiological data, together with the close phylogenetic relationship of S . stercoralis with S . procyonis , a Strongyloides parasite of raccoons, possibly indicates that S . stercoralis originally evolved as a canid parasite, and later spread into humans. The inability to infect humans might be an ancestral character of this species and the type B might be surmised to be an origin population from which human-infecting strains are derived. Abstract Humans and dogs are the two major hosts of Strongyloides stercoralis, an intestinal parasitic nematode. To better understand the phylogenetic relationships among S. stercoralis isolates infecting humans and dogs and to assess the zoonotic potential of this parasite, we analyzed mitochondrial Cox1, nuclear 18S rDNA, 28S rDNA, and a major sperm protein domain-containing protein genes. Overall, our analyses indicated the presence of two distinct lineages of S. stercoralis (referred to as type A and type B). While type A parasites were isolated both from humans and dogs in different countries, type B parasites were found exclusively in dogs, indicating that the type B has not adapted to infect humans. These epidemiological data, together with the close phylogenetic relationship of S. stercoralis with S. procyonis, a Strongyloides parasite of raccoons, possibly indicates that S. stercoralis originally evolved as a canid parasite, and later spread into humans. The inability to infect humans might be an ancestral character of this species and the type B might be surmised to be an origin population from which human-infecting strains are derived. |
| ArticleNumber | 4844 |
| Author | Odongo-Aginya, Emmanuel Igwaro Tanaka, Teruhisa Aye, Khin Myo Htike, Wah Win Panthuwong, Siripen Olia, Alex Hino, Akina Nagayasu, Eiji Taniguchi, Tomoyo Aung, Myo Pa Pa Thet Hnin Htwe Hortiwakul, Thanaporn Horii, Toshihiro Hisaeda, Hajime Palacpac, Nirianne M Q Torisu, Shidow Win, Kyu Kyu Kikuchi, Taisei Ota, Kei Maruyama, Haruhiko Torisu, Yukari Mon, Mon Higashiarakawa, Miwa Hirata, Tetsuo Ohashi, Isao Fujita, Jiro Win, Soe Moe Thu Kimura, Eisaku |
| Author_xml | – sequence: 1 givenname: Eiji surname: Nagayasu fullname: Nagayasu, Eiji organization: Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan – sequence: 2 givenname: Myo Pa Pa Thet Hnin Htwe surname: Aung fullname: Aung, Myo Pa Pa Thet Hnin Htwe organization: Department of Microbiology, University of Medicine 1, Yangon, Republic of the Union of Myanmar – sequence: 3 givenname: Thanaporn surname: Hortiwakul fullname: Hortiwakul, Thanaporn organization: Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand – sequence: 4 givenname: Akina surname: Hino fullname: Hino, Akina organization: Department of Environmental Parasitology, Tokyo Medical and Dental University, Tokyo, Japan – sequence: 5 givenname: Teruhisa surname: Tanaka fullname: Tanaka, Teruhisa organization: Department of Endoscopy, University of the Ryukyus Hospital, Okinawa, Japan – sequence: 6 givenname: Miwa surname: Higashiarakawa fullname: Higashiarakawa, Miwa organization: Department of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan – sequence: 7 givenname: Alex surname: Olia fullname: Olia, Alex organization: Department of Parasitology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan – sequence: 8 givenname: Tomoyo surname: Taniguchi fullname: Taniguchi, Tomoyo organization: Department of Parasitology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan – sequence: 9 givenname: Soe Moe Thu surname: Win fullname: Win, Soe Moe Thu organization: Department of Microbiology, University of Medicine 1, Yangon, Republic of the Union of Myanmar – sequence: 10 givenname: Isao surname: Ohashi fullname: Ohashi, Isao organization: Department of Medical Technology, Koshimizu Red Cross Hospital, Koshimizu, Japan – sequence: 11 givenname: Emmanuel Igwaro surname: Odongo-Aginya fullname: Odongo-Aginya, Emmanuel Igwaro organization: Department of Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda – sequence: 12 givenname: Khin Myo surname: Aye fullname: Aye, Khin Myo organization: Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan – sequence: 13 givenname: Mon surname: Mon fullname: Mon, Mon organization: Department of Microbiology, University of Medicine 1, Yangon, Republic of the Union of Myanmar – sequence: 14 givenname: Kyu Kyu surname: Win fullname: Win, Kyu Kyu organization: Department of Microbiology, University of Medicine 1, Yangon, Republic of the Union of Myanmar – sequence: 15 givenname: Kei surname: Ota fullname: Ota, Kei organization: Department of Emergency and General Medicine, Koshimizu Red Cross Hospital, Koshimizu, Japan – sequence: 16 givenname: Yukari surname: Torisu fullname: Torisu, Yukari organization: Section of Oncopathology and Regenerative Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan – sequence: 17 givenname: Siripen surname: Panthuwong fullname: Panthuwong, Siripen organization: Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand – sequence: 18 givenname: Eisaku surname: Kimura fullname: Kimura, Eisaku organization: Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan – sequence: 19 givenname: Nirianne M Q orcidid: 0000-0003-4098-3972 surname: Palacpac fullname: Palacpac, Nirianne M Q organization: Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan – sequence: 20 givenname: Taisei surname: Kikuchi fullname: Kikuchi, Taisei organization: Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan – sequence: 21 givenname: Tetsuo surname: Hirata fullname: Hirata, Tetsuo organization: Department of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan – sequence: 22 givenname: Shidow surname: Torisu fullname: Torisu, Shidow organization: Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan – sequence: 23 givenname: Hajime surname: Hisaeda fullname: Hisaeda, Hajime organization: Department of Parasitology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan – sequence: 24 givenname: Toshihiro surname: Horii fullname: Horii, Toshihiro organization: Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan – sequence: 25 givenname: Jiro surname: Fujita fullname: Fujita, Jiro organization: Department of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan – sequence: 26 givenname: Wah Win surname: Htike fullname: Htike, Wah Win organization: Department of Microbiology, University of Medicine 1, Yangon, Republic of the Union of Myanmar – sequence: 27 givenname: Haruhiko surname: Maruyama fullname: Maruyama, Haruhiko email: hikomaru@med.miyazaki-u.ac.jp organization: Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. hikomaru@med.miyazaki-u.ac.jp |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28687738$$D View this record in MEDLINE/PubMed |
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| Snippet | Humans and dogs are the two major hosts of Strongyloides stercoralis, an intestinal parasitic nematode. To better understand the phylogenetic relationships... Abstract Humans and dogs are the two major hosts of Strongyloides stercoralis , an intestinal parasitic nematode. To better understand the phylogenetic... Humans and dogs are the two major hosts of Strongyloides stercoralis , an intestinal parasitic nematode. To better understand the phylogenetic relationships... Abstract Humans and dogs are the two major hosts of Strongyloides stercoralis, an intestinal parasitic nematode. To better understand the phylogenetic... |
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| SubjectTerms | Intestine Mitochondria Pandemics Parasites Parasitic diseases Phylogenetics Phylogeny Strongyloides stercoralis |
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| Title | A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny |
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