The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron

• Published in: Emerging microbes & infections Vol. 11; no. 1; pp. 1 - 5
• Main Authors: Zhang, Li, Li, Qianqian, Liang, Ziteng, Li, Tao, Liu, Shuo, Cui, Qianqian, Nie, Jianhui, Wu, Qian, Qu, Xiaowang, Huang, Weijin, Wang, Youchun
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: BA.1; convalescence serum; Coronaviruses; COVID-19 - immunology; COVID-19 - virology; COVID-19 vaccines; Host-Pathogen Interactions - immunology; Humans; Immune Evasion; Mutation; neutralization; SARS-CoV-2; SARS-CoV-2 - classification; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Viral Pseudotyping; VOC; SARS-CoV-2; VOC; convalescence serum; BA.1; neutralization

The emergence of Omicron/BA.1 has brought new challenges to fight against SARS-CoV-2. A large number of mutations in the Spike protein suggest that its susceptibility to immune protection elicited by the existing COVID-19 infection and vaccines may be altered. In this study, we constructed the pseud...