Protection from environmental enteric dysfunction and growth improvement in malnourished newborns by amplification of secretory IgA

• Published in: Cell reports. Medicine Vol. 5; no. 7; p. 101639
• Main Authors: Perruzza, Lisa, Rezzonico Jost, Tanja, Raneri, Matteo, Gargari, Giorgio, Palatella, Martina, De Ponte Conti, Benedetta, Seehusen, Frauke, Heckmann, Julia, Viemann, Dorothee, Guglielmetti, Simone, Grassi, Fabio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.07.2024; Elsevier
• Subjects: Advanced Basic Science; Animals; Animals, Newborn; Apyrase - metabolism; breast milk; environmental enteric dysfunction; Female; Gastrointestinal Microbiome; Humans; Immunoglobulin A, Secretory - metabolism; Infant, Newborn; live biotherapeutic; malnutrition; Malnutrition - immunology; Mice; microbiota; mucosal immunity; purinergic signaling; secretory immunoglobulin; T follicular helper cell; microbiota; malnutrition; purinergic signaling; environmental enteric dysfunction; breast milk; secretory immunoglobulin; live biotherapeutic; T follicular helper cell; mucosal immunity

Environmental enteric dysfunction (EED) is a condition associated with malnutrition that can progress to malabsorption and villous atrophy. Severe EED results in linear growth stunting, slowed neurocognitive development, and unresponsiveness to oral vaccines. Prenatal exposure to malnutrition and br...