Dual-responsive nanosystem based on TGF-β blockade and immunogenic chemotherapy for effective chemoimmunotherapy

• Published in: Drug delivery Vol. 29; no. 1; pp. 1358 - 1369
• Main Authors: Huang, Xiaoxian, Han, Lingfei, Wang, Ruyi, Zhu, Wanfang, Zhang, Ning, Qu, Wei, Liu, Wenyuan, Liu, Fulei, Feng, Feng, Xue, Jingwei
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Apoptosis; Cancer; Cell culture; Cell death; Chemoimmunotherapy; Chemotherapy; Cytokines; Cytotoxicity; Extracellular matrix; Hypoxia; immunogenic cell death; immunosuppression tumor microenvironment; Immunotherapy; Kinases; Laboratories; Metastasis; Micelles; nanosystem; Pharmaceutical sciences; Prodrugs - pharmacology; TGF-β blockade; Transforming Growth Factor beta; Tumor Microenvironment; Tumors; immunosuppression tumor microenvironment; Chemoimmunotherapy; TGF-β blockade; nanosystem; immunogenic cell death

The antitumor immune response induced by chemotherapy has attracted considerable attention. However, the immunosuppressive tumor microenvironment hinders the immune activation effect of cancer chemotherapy. TGF-β plays a key role in driving tumor immunosuppression and can prevent effective antitumor...