Dissemination and genome analysis of high-level ceftriaxone-resistant penA 60.001 Neisseria gonorrhoeae strains from the Guangdong Gonococcal antibiotics susceptibility Programme (GD-GASP), 2016-2019

• Published in: Emerging microbes & infections Vol. 11; no. 1; pp. 344 - 350
• Main Authors: Lin, Xiaomian, Chen, Wentao, Xie, Qinghui, Yu, Yuqi, Liao, Yiwen, Feng, Zhanjin, Qin, Xiaolin, Wu, Xingzhong, Tang, Sanmei, Zheng, Heping
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Anti-Bacterial Agents - pharmacology; Antibiotics; Antimicrobial Agents; Azithromycin - pharmacology; Ceftriaxone - pharmacology; ceftriaxone-resistant; China - epidemiology; Ciprofloxacin - pharmacology; Drug resistance; Drug Resistance, Bacterial; epidemiological investigation; Genome, Bacterial; Genomes; Gonorrhea; Gonorrhea - drug therapy; Gonorrhea - microbiology; Humans; Microbial Sensitivity Tests; Molecular Epidemiology; Multilocus Sequence Typing; N. gonorrhoeae; Neisseria gonorrhoeae - classification; Neisseria gonorrhoeae - drug effects; Neisseria gonorrhoeae - genetics; Neisseria gonorrhoeae - isolation & purification; penA 60.001; Penicillin; Spectinomycin - pharmacology; China; N. gonorrhoeae; ceftriaxone-resistant; epidemiological investigation; penA 60.001

Background: After Neisseria gonorrhoeae FC428 was first found in Japan, ceftriaxone-resistant strains disseminated globally, and the gonococcal resistance rate increased remarkably. Epidemiological investigations are greatly significant for the analysis of antimicrobial resistance (AMR) trends, mole...