Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection

• Published in: Cell reports (Cambridge) Vol. 33; no. 5; p. 108345
• Main Authors: Irving, Aaron T., Zhang, Qian, Kong, Pui-San, Luko, Katarina, Rozario, Pritisha, Wen, Ming, Zhu, Feng, Zhou, Peng, Ng, Justin H.J., Sobota, Radoslaw M., Wang, Lin-Fa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.11.2020; The Author(s); Elsevier
• Subjects: Animals; bat; Chiroptera - immunology; Gene Expression Regulation - immunology; Herpesvirus 1, Human - immunology; IAV; Influenza A virus - immunology; innate immunity; interferon; Interferon Regulatory Factor; Interferon Regulatory Factor-1 - immunology; Interferon Regulatory Factor-7 - immunology; IRF; IRG; MERS; Middle East Respiratory Syndrome Coronavirus - immunology; Orthoreovirus - immunology; PRV3M; virus; Virus Diseases - immunology; Interferon Regulatory Factor; PRV3M; bat; innate immunity; IRF; interferon; MERS; virus; IAV; IRG

Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and that, basally, IRFs contribute to the expression of type...