Integrative modeling reveals the principles of multi-scale chromatin boundary formation in human nuclear organization

• Published in: Genome Biology Vol. 16; no. 1; p. 110
• Main Authors: Moore, Benjamin L, Aitken, Stuart, Semple, Colin A
• Format: Journal Article
• Language: English
• Published: England BioMed Central 27.05.2015
• Subjects: Boundaries; CCCTC-Binding Factor; Cell cycle; Cell Line; Chromatin; Chromatin - genetics; Chromosomes; Comparative analysis; Data collection; Databases, Genetic; Datasets; Deoxyribonucleic acid; DNA; DNA methylation; DNA Replication Timing; DNA-binding protein; DNA-Binding Proteins - genetics; Epigenesis, Genetic; Genetic Loci; Genomes; Humans; K562 Cells; Models, Molecular; Multigene Family; Proteins; Regulation; Repressor Proteins - genetics; Repressor Proteins - metabolism; Stem cells; Transcription factors

Interphase chromosomes adopt a hierarchical structure, and recent data have characterized their chromatin organization at very different scales, from sub-genic regions associated with DNA-binding proteins at the order of tens or hundreds of bases, through larger regions with active or repressed chro...